ArticleFrontiers in genetics2020
Haplotype-Based, Genome-Wide Association Study Reveals Stable Genomic Regions for Grain Yield in CIMMYT Spring Bread Wheat.
Article in Frontiers in genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Genetic dissection of cold tolerance across developmental stages in sorghum reveals stage-specific haplotypes and potential trade-offs.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Harnessing genomics approaches for heat stress resilience in wheat: from discovery to deployment.Journal of experimental botany · 2026Review
- Large scale wheat data integration improves genomic prediction accuracy with the potential to facilitate international breeding collaborations.Communications biology · 2026Article
- Haplotype-based genome-wide association study uncovers QTL for fruit-related traits in the 287 tomato accessions.BMC plant biology · 2026Article
- Molecular mapping of QTLs for stripe rust resistance in bread wheat (Triticum aestivum L.).BMC plant biology · 2026Article
- Advances and prospects of genomic-assisted breeding in roots, tubers, and banana crops.Frontiers in plant science · 2026Review
- QTL mapping for leaf rust resistance in bread wheat using PBW343/W8627 RIL population.Frontiers in plant science · 2026Article
- Dissecting the genetic architecture of pre-harvest sprouting tolerance in Indian dwarf wheat (Triticum sphaerococcum) by multi-locus association analysis.Scientific reports · 2025Article
- Association studies for leaf rust resistance earmark differential genomic regions for silicon (Si) responsiveness in bread wheat (Triticum aestivum L.).BMC plant biology · 2025Article
- Review
- Genome-wide association study of seedling-plant resistance to stripe rust in bread wheat (Frontiers in plant science · 2025Article
- Genome-wide association study and expression of candidate genes for Fe and Zn concentration in sorghum grains.Scientific reports · 2024Article
- Genome-wide scanning to identify and validate single nucleotide polymorphism markers associated with drought tolerance in spring wheat seedlings.The plant genome · 2024Article
- Genomic wide association study and selective sweep analysis identify genes associated with improved yield under drought in Turkish winter wheat germplasm.Scientific reports · 2024Article
- Genome-wide association study of drought tolerance in wheat (Triticum aestivum L.) identifies SNP markers and candidate genes.Molecular genetics and genomics : MGG · 2024Article
- Using chlorophyll fluorescence parameters and antioxidant enzyme activity to assess drought tolerance of spring wheat.Photosynthetica · 2024Article
- Review
- Evolutionarily recent retrotransposons contribute to schizophrenia.Translational psychiatry · 2023Article
- Haplotype-tagged SNPs improve genomic prediction accuracy for Fusarium head blight resistance and yield-related traits in wheat.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- Wheat Omics: Advancements and Opportunities.Plants (Basel, Switzerland) · 2023Review
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10 authors.
Funding
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Abstract
We untangled key regions of the genetic architecture of grain yield (GY) in CIMMYT spring bread wheat by conducting a haplotype-based, genome-wide association study (GWAS), together with an investigation of epistatic interactions using seven large sets of elite yield trials (EYTs) consisting of a total of 6,461 advanced breeding lines. These lines were phenotyped under irrigated and stress environments in seven growing seasons (2011-2018) and genotyped with genotyping-by-sequencing markers. Genome-wide 519 haplotype blocks were constructed, using a linkage disequilibrium-based approach covering 14,036 Mb in the wheat genome. Haplotype-based GWAS identified 7, 4, 10, and 15 stable (significant in three or more EYTs) associations in irrigated (I), mild drought (MD), severe drought (SD), and heat stress (HS) testing environments, respectively. Considering all EYTs and the four testing environments together, 30 stable associations were deciphered with seven hotspots identified on chromosomes 1A, 1B, 2B, 4A, 5B, 6B, and 7B, where multiple haplotype blocks were associated with GY. Epistatic interactions contributed significantly to the genetic architecture of GY, explaining variation of 3.5-21.1%, 3.7-14.7%, 3.5-20.6%, and 4.4- 23.1% in I, MD, SD, and HS environments, respectively. Our results revealed the intricate genetic architecture of GY, controlled by both main and epistatic effects. The importance of these results for practical applications in the CIMMYT breeding program is discussed.
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