Evidence map›Paper›PMID 33335287›Full record

ArticleCell death and differentiation2021

Ferroptotic pores induce Ca

Lohans Pedrera, Rafael A Espiritu, Uris Ros, Josephine Weber, Anja Schmitt, Jenny Stroh, Stephan Hailfinger, Silvia von Karstedt, Ana J García-Sáez

Open access · hybridAbstract read
In one paragraph

Article in Cell death and differentiation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 206 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
206citing papers in PubMed, 1 pooled it
16.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

206 citing papers in PubMed, 1 synthesis or guideline pooled it, 278 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Review
  6. Ferroptosis in liver biology and diseases.Hepatology communications · 2026
    Review
  7. Review
  8. Review
  9. The Emerging Role of Ferroptosis in Pediatric Cancer Biology and Therapy.International journal of molecular sciences · 2026
    Review
  10. Review
  11. Review
  12. Structural and molecular principles of DAMP biology.Nature structural & molecular biology · 2026
    Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article

146 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Lohans Pedrera *Institute for Genetics, University of Cologne, Joseph-Stelzmann-Straße 26, 50931, Cologne, Germany.
Rafael A Espiritu *Interfaculty Institute of Biochemistry, Eberhard-Karls-Universität Tübingen, 72076, Tübingen, Germany.ORCID http://orcid.org/0000-0001-9993-4310
Uris RosInstitute for Genetics, University of Cologne, Joseph-Stelzmann-Straße 26, 50931, Cologne, Germany.
Josephine WeberCECAD Cluster of Excellence, University of Cologne, Joseph-Stelzmann-Straße 26, 50931, Cologne, Germany.
Anja SchmittInterfaculty Institute of Biochemistry, Eberhard-Karls-Universität Tübingen, 72076, Tübingen, Germany.
Jenny StrohCECAD Cluster of Excellence, University of Cologne, Joseph-Stelzmann-Straße 26, 50931, Cologne, Germany.
Stephan HailfingerInterfaculty Institute of Biochemistry, Eberhard-Karls-Universität Tübingen, 72076, Tübingen, Germany.
Silvia von KarstedtCECAD Cluster of Excellence, University of Cologne, Joseph-Stelzmann-Straße 26, 50931, Cologne, Germany.ORCID http://orcid.org/0000-0002-7816-5919
Ana J García-SáezInstitute for Genetics, University of Cologne, Joseph-Stelzmann-Straße 26, 50931, Cologne, Germany. ana.garcia@uni-koeln.de.ORCID http://orcid.org/0000-0002-3894-5945
University of Cologne · DEUniversity of Tübingen · DEDe La Salle University · PH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ferroptosis is an iron-dependent form of regulated necrosis associated with lipid peroxidation. Despite its key role in the inflammatory outcome of ferroptosis, little is known about the molecular events leading to the disruption of the plasma membrane during this type of cell death. Here we show that a sustained increase in cytosolic Ca

Indexed as

CalciumCell DeathEndosomal Sorting Complexes Required for TransportFerroptosisHumansKineticsTransfectionCalciumEndosomal Sorting Complexes Required for Transport

Identifiers

PMID33335287
PMCPMC8167089
OpenAlexW3112044135

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.