ArticleScientific reports2020
Automated diffusion-based parcellation of the hypothalamus reveals subunit-specific associations with obesity.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The solitary nucleus connectivity to key autonomic regions in humans.The European journal of neuroscience · 2022Pooled it
- Disrupted neurovascular-endocrine coupling in type 1 diabetes with impaired awareness of hypoglycemia.The Journal of clinical investigation · 2026Article
- Latent brain-cognition dimension indicative of neuroinflammatory basis of Long COVID.Brain communications · 2026Article
- Increased Glymphatic System Activity and Hypothalamic Connectivity in Patients With Premenstrual Dysphoric Disorder.Depression and anxiety · 2026Article
- Neural pathways to bariatric success: What explainable AI reveals that conventional fMRI methods may miss.Diabetes, obesity & metabolism · 2025Article
- Hypothalamic volume, sleep, and APOE genotype in cognitively healthy adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Exploring the link between inflammation and brain function after metabolic-bariatric surgery: A year-long fMRI study.Diabetes, obesity & metabolism · 2025Article
- Sleep quality and the integrity of ascending reticular activating system - A multimodal MRI study.Heliyon · 2024Article
- Manual segmentation of the paraventricular nucleus of the hypothalamus and the dorsal and ventral bed nucleus of stria terminalis using multimodal 7 Tesla structural MRI: probabilistic atlases for a stress-control triad.Brain structure & function · 2024Article
- Dysfunction of the hypothalamic-pituitary adrenal axis and its influence on aging: the role of the hypothalamus.Scientific reports · 2023Article
- Brain functional and structural magnetic resonance imaging of obesity and weight loss interventions.Molecular psychiatry · 2023Review
- The Significance of Hypothalamic Inflammation and Gliosis for the Pathogenesis of Obesity in Humans.Endocrine reviews · 2023Review
- Hypothalamic microstructure and function are related to body mass, but not mental or cognitive abilities across the adult lifespan.GeroScience · 2023Article
- Hypothalamic volume is associated with body mass index.NeuroImage. Clinical · 2023Article
- Maternal free fatty acid concentration during pregnancy is associated with newborn hypothalamic microstructure in humans.Obesity (Silver Spring, Md.) · 2022Article
- Lower hypothalamus subunit volumes link with impaired long-term body weight gain after preterm birth.Frontiers in endocrinology · 2022Article
- Morphological alterations of the hypothalamus in idiopathic intracranial hypertension.Therapeutic advances in chronic disease · 2022Article
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3 authors.
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Abstract
The hypothalamus is a small, yet highly versatile structure mainly involved in bodily functions such as control of food intake and endocrine activity. Functional anatomy of different hypothalamic areas is mainly investigated using structural MRI, validated by ex-vivo histological studies. Based on diffusion-weighted imaging (DWI), recent automated clustering methods provide robust tools for parcellation. Using data of 100 healthy adults provided by the Human Connectome Project Database, we applied DWI-based automated clustering to the hypothalamus and related microstructural properties in these hypothalamic compartments to obesity. Our results suggest that the hypothalamus can be reliably partitioned into four clusters in each hemisphere using diffusion-based parcellation. These correspond to an anterior-superior, anterior-inferior, intermediate, and posterior cluster. Obesity was predicted by mean diffusivity of the anterior-superior cluster, suggesting altered inhibition of food intake. The proposed method provides an automated hypothalamic parcellation technique based on DWI data to explore anatomy and function of hypothalamic subunits in vivo in humans.
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