ArticleScientific reports2020
Parallel modulation of intracortical excitability of somatosensory and visual cortex by the gonadal hormones estradiol and progesterone.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 21 citations in OpenAlex.
- Pubertal Hormones and the Early Adolescent Female Brain: A Multimodality Brain MRI Study.Human brain mapping · 2026Article
- Sex differences in resting state EEG spectral power are more prominent than menstrual cycle effects in healthy young adults.Frontiers in endocrinology · 2026Article
- Utilizing resting motor threshold to predict cognitive function in drug-naive patients with major depressive disorder.BMC psychiatry · 2025Article
- Do Hormonal Fluctuations in Healthy Women Influence the Somatosensory Temporal Discrimination Threshold?Brain and behavior · 2025Article
- Disruptive compensatory mechanisms in fibromyalgia syndrome and their association with pharmacological agents.Experimental brain research · 2024Article
- Article
- The effects of estradiol levels on crossmodal perception: a study on the sound induced flash illusion in healthy and menstrually related migraine individuals.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Article
- Sex Differences in Excitatory and Inhibitory Function in the Primary Somatosensory Cortex during the Early Follicular Phase: A Preliminary Study.Brain sciences · 2023Article
- Biomarkers for rapid H-reflex operant conditioning among females.Journal of neurophysiology · 2023Article
- Cortical excitability in human somatosensory and visual cortex: implications for plasticity and learning - a minireview.Frontiers in human neuroscience · 2023Review
- Changes in Visual Long-Term Potentiation Show Preserved Cyclicity in Human Females Taking Combined Oral Contraceptives.Neuroendocrinology · 2023Article
- Sensorimotor performance after high-definition transcranial direct current stimulation over the primary somatosensory or motor cortices in men versus women.Scientific reports · 2022Article
- Gray Matter Volume Variability in Young Healthy Adults: Influence of Gender Difference and Brain-Derived Neurotrophic Factor Genotype.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Article
- Altered Visual Cortical Excitability Is Associated With Psychopathological Symptoms in Major Depressive Disorder.Frontiers in psychiatry · 2022Article
- Low test-retest reliability of a protocol for assessing somatosensory cortex excitability generated from sensory nerves of the lower back.Frontiers in human neuroscience · 2022Article
- Intermittent Theta-Burst Stimulation Over the DorsoLateral PreFrontal Cortex (DLPFC) in Healthy Subjects Produces No Cumulative Effect on Cortical Excitability.Frontiers in psychiatry · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The levels of the gonadal hormones estradiol and progesterone vary throughout the menstrual cycle thereby affecting cognition, emotion, mood, and social behaviour. However, how these hormones modulate the balance of neural excitation and inhibition, which crucially regulate processing and plasticity, is not fully understood. We here used paired-pulse stimulation to investigate in healthy humans the action of low and high estradiol and progesterone on intracortical inhibition in somatosensory (SI) and visual cortex (V1). We found that paired-pulse suppression in both SI and VI depended on estradiol. During high estradiol levels, paired-pulse suppression was significantly reduced. No comparable effects were found for progesterone, presumably due to a confounding effect of estradiol. Also, no hormone level-depending effects were observed for single-pulse evoked SEPs (somatosensory evoked potentials) and VEPs (visual evoked potentials) indicating a specific hormonal action on intracortical processing. The results demonstrate that estradiol globally modulates the balance of excitation and inhibition of SI and VI cortex.
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