Evidence map›Paper›PMID 33335210›Full record

ArticleScientific reports2020

Single-walled carbon nanotubes as a photo-thermo-acoustic cancer theranostic agent: theory and proof of the concept experiment.

L Golubewa, I Timoshchenko, O Romanov, R Karpicz, T Kulahava, D Rutkauskas, M Shuba, A Dementjev, Yu Svirko, P Kuzhir

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 45 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 4 countries.

L GolubewaCenter for Physical Sciences and Technology, Sauletekio Ave. 3, 10257, Vilnius, Lithuania. lena.golubewa@ftmc.lt.ORCID 0000-0003-2125-6366
I TimoshchenkoBelarusian State University, Nezavisimosti Ave. 4, 220030, Minsk, Belarus.ORCID 0000-0003-2830-9213
O RomanovBelarusian State University, Nezavisimosti Ave. 4, 220030, Minsk, Belarus.ORCID 0000-0002-3988-8081
R KarpiczCenter for Physical Sciences and Technology, Sauletekio Ave. 3, 10257, Vilnius, Lithuania.ORCID 0000-0001-5884-4538
T KulahavaInstitute for Nuclear Problems, Belarusian State University, Bobruiskaya 11, 220006, Minsk, Belarus.ORCID 0000-0002-1113-7323
D RutkauskasCenter for Physical Sciences and Technology, Sauletekio Ave. 3, 10257, Vilnius, Lithuania.ORCID 0000-0003-4705-2222
M ShubaInstitute for Nuclear Problems, Belarusian State University, Bobruiskaya 11, 220006, Minsk, Belarus.ORCID 0000-0003-4828-7242
A DementjevCenter for Physical Sciences and Technology, Sauletekio Ave. 3, 10257, Vilnius, Lithuania.ORCID 0000-0002-4236-3147
Yu SvirkoInstitute of Photonics, University of Eastern Finland, Yliopistokatu 7, 80100, Joensuu, Finland.ORCID 0000-0002-2927-6233
P KuzhirInstitute for Nuclear Problems, Belarusian State University, Bobruiskaya 11, 220006, Minsk, Belarus.ORCID 0000-0003-3689-0837
Belarusian State University · BYCenter for Physical Sciences and Technology · LTUniversity of Eastern Finland · FINational Research Tomsk State University · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Theranostics is the emerging field of medicine that uniquely combines diagnostic techniques and active agents to diagnose and treat medical conditions simultaneously or sequentially. Finding a theranostic agent capable to cure the affected cells and being safe for the healthy ones is the key for successful treatment. Here, we demonstrate that agglomerated single-walled carbon nanotubes (SWCNTs) are promising theranostic agent that enables photo-activated 'cold' destruction of the cancer cells keeping their environment alive. The absorption of picosecond pulses by SWCNT agglomerates results in the mechanical (due to photoacoustic effect) rather than photothermal cancer cell destruction, which was visualized by micro-Raman and ultrafast near-infrared CARS. The developed theoretical model allows us to distinguish photothermal, photoacoustic, and photothermoacoustic regimes of the cancer cell destruction, and also to optimize SWCNT-based theranostics recipe.

Indexed as

Nanotubes, CarbonTheranostic NanomedicineAnimalsCell Culture TechniquesCell Line, TumorCell SurvivalHumansModels, TheoreticalNanotechnologyNeoplasmsPrecision MedicineProof of Concept StudyRatsTocopherolsNanotubes, CarbonTocopherols

Identifiers

PMID33335210
PMCPMC7746693
OpenAlexW3113361891

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.