ArticleScientific reports2020
Serum amyloid A is a positive acute phase protein in Russian sturgeon challenged with Aeromonas hydrophila.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 46 citations in OpenAlex.
- Evaluation of minimally invasive metabolomic methods for assessing the health of sturgeons.Scientific reports · 2025Article
- Cellular responses in rainbow trout Oncorhynchus mykiss to experimental Anisakis simplex infection.Parasitology research · 2025Article
- Molecular Characterization of Hemopexin in the Siberian Sturgeon (International journal of molecular sciences · 2025Article
- Spatiotemporal Dynamics of Pro-Inflammatory Mediator Expression inAnimals : an open access journal from MDPI · 2025Article
- Tryptophan-induced transcriptomic changes in the European Seabass are highly dependent on neuroendocrine-immune conditions.Scientific reports · 2025Article
- Protective immune response in rainbow trout (Frontiers in immunology · 2025Article
- Article
- Innate immune and chronic heat stress responses in sturgeons: Advances and insights from studies on Russian sturgeons.Fish and shellfish immunology reports · 2023Article
- Catch of the Day: New Serum Amyloid A (SAA) Antibody Is a Valuable Tool to Study Fish Health in Salmonids.Cells · 2023Article
- B-glucan immunostilulation against columnaris in a white sturgeon (Acipenser transmontanus) model.Fish and shellfish immunology reports · 2022Article
- Evaluation of fetal heart serum amyloid a concentrations in infectious cattle abortion cases.Heliyon · 2022Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The immune system of sturgeons, one of the most ancient and economically valuable fish worldwide, is poorly understood. The lack of molecular tools and data about infection biomarkers hinders the possibility to monitor sturgeon health during farming and detect infection outbreaks. To tackle this issue, we mined publicly available transcriptomic datasets and identified putative positive acute-phase proteins (APPs) of Russian sturgeons that could be induced by a bacterial infection and monitored using non-invasive methods. Teleost literature compelled us to focus on five promising candidates: hepcidin, a warm acclimation associated hemopexin, intelectin, serum amyloid A protein (SAA) and serotransferrin. Among them, SAA was the most upregulated protein at the mRNA level in the liver of sturgeons challenged with heat-inactivated or live Aeromonas hydrophila. To assess whether this upregulation yielded increasing SAA levels in circulation, we developed an in-house ELISA to quantify SAA levels in sturgeon serum. Circulating SAA rose upon bacterial challenge and positively correlated with hepatic saa expression. This is the first time serum SAA has been quantified in an Actinopterygii fish. Since APPs vary across different fish species, our work sheds light on sturgeon acute-phase response, revealing that SAA is a positive APP with potential value as infection biomarker.
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