Evidence map›Paper›PMID 33335119›Full record

ArticleScientific reports2020

Cell non-autonomous requirement of p75 in the development of geniculate oral sensory neurons.

Tao Tang, Christopher R Donnelly, Amol A Shah, Robert M Bradley, Charlotte M Mistretta, Brian A Pierchala

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
  3. Wiring the senses: Factors that regulate peripheral axon pathfinding in sensory systems.Developmental dynamics : an official publication of the American Association of Anatomists · 2023
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Tao TangDepartment of Biologic and Materials Sciences, University of Michigan School of Dentistry, Ann Arbor, MI, 48109, USA.
Christopher R DonnellyDepartment of Biologic and Materials Sciences, University of Michigan School of Dentistry, Ann Arbor, MI, 48109, USA.
Amol A ShahDepartment of Biologic and Materials Sciences, University of Michigan School of Dentistry, Ann Arbor, MI, 48109, USA.
Robert M BradleyDepartment of Biologic and Materials Sciences, University of Michigan School of Dentistry, Ann Arbor, MI, 48109, USA.
Charlotte M MistrettaDepartment of Biologic and Materials Sciences, University of Michigan School of Dentistry, Ann Arbor, MI, 48109, USA.
Brian A PierchalaDepartment of Biologic and Materials Sciences, University of Michigan School of Dentistry, Ann Arbor, MI, 48109, USA. brpierch@iu.edu.
University of Michigan–Ann Arbor · USDuke University · USIndiana University – Purdue University Indianapolis · USIndiana University School of Medicine

Funding

Tissue Engineering and RegenerationT32DE007057 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAVID H. KOHN · 1985 to 2026
$17.3M
Growth factors in the development and physiology of geniculate taste neuronsR01DC015799 · NIDCD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Brian Anthony Pierchala · 2017 to 2026
$4.8M
A p75/Ret Receptor Complex as an Integrator of Survival and DeathR01NS089585 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PIERCHALA, BRIAN ANTHONY · 2015 to 2024
$3.9M
Hedgehog signaling in maintaining taste organ structure and function: basic and clinical studiesR01DC014428 · NIDCD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ALLEN, BENJAMIN, BRADLEY, ROBERT M · 2015 to 2019
$3.3M
Understanding the Function of GFL-Ret Signaling in the Development of the PeripheF30DE023479 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DONNELLY, CHRISTOPHER RYAN · 2014 to 2017
$189k
NIDCD NIH HHS R01 DC014428NIDCD NIH HHS R01 DC015799NIDCR NIH HHS F30 DE023479NIDCR NIH HHS T32 DE007057NINDS NIH HHS R01 NS089585
6 · The paper itself

Abstract

During development of the peripheral taste system, oral sensory neurons of the geniculate ganglion project via the chorda tympani nerve to innervate taste buds in fungiform papillae. Germline deletion of the p75 neurotrophin receptor causes dramatic axon guidance and branching deficits, leading to a loss of geniculate neurons. To determine whether the developmental functions of p75 in geniculate neurons are cell autonomous, we deleted p75 specifically in Phox2b + oral sensory neurons (Phox2b-Cre; p75

Indexed as

AllelesAnimalsBiomarkersChorda Tympani NerveFluorescent Antibody TechniqueGeniculate GanglionGenotypeImmunohistochemistryMiceMice, KnockoutMice, TransgenicReceptors, Nerve Growth FactorSensory Receptor CellsTasteTouchBiomarkersNgfr protein, mouseReceptors, Nerve Growth Factor

Identifiers

PMID33335119
PMCPMC7747618
OpenAlexW3113052413

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.