Evidence map›Paper›PMID 33335111›Full record

ArticleScientific reports2020

Multimodal fusion with deep neural networks for leveraging CT imaging and electronic health record: a case-study in pulmonary embolism detection.

Shih-Cheng Huang, Anuj Pareek, Roham Zamanian, Imon Banerjee, Matthew P Lungren

Abstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

80 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
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  11. Multimodal Wearable Biosensing Meets Multidomain AI: A Pathway to Decentralized Healthcare.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
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  15. Deep learning in the early diagnosis of acute aortic dissection.Frontiers in cardiovascular medicine · 2026
    Review
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20 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Shih-Cheng HuangDepartment of Biomedical Data Science, Stanford University, Stanford, USA. mschuang@stanford.edu.
Anuj PareekCenter for Artificial Intelligence in Medicine and Imaging, Stanford University, Stanford, USA.
Roham ZamanianDepartment of Pulmonary Critical Care Medicine, Stanford University, Stanford, USA.
Imon BanerjeeCenter for Artificial Intelligence in Medicine and Imaging, Stanford University, Stanford, USA.
Matthew P LungrenDepartment of Biomedical Data Science, Stanford University, Stanford, USA.

Funding

Population-level Pulmonary Embolism Outcome Prediction with Imaging and Clinical Data: A Multi-Center StudyR01HL155410 · NHLBI · STANFORD UNIVERSITY · PI LANGLOTZ, CURTIS P, SHAH, NIGAM H · 2021 to 2024
$2.1M
Deep Learning for Pulmonary Embolism Imaging Decision Support: A Multi-institutional CollaborationR01LM012966 · NLM · STANFORD UNIVERSITY · PI SHAH, NIGAM H · 2018 to 2021
$1.4M
NHLBI NIH HHS R01 HL155410NLM NIH HHS R01 LM012966NLM NIH HHS R01LM012966
6 · The paper itself

Abstract

Recent advancements in deep learning have led to a resurgence of medical imaging and Electronic Medical Record (EMR) models for a variety of applications, including clinical decision support, automated workflow triage, clinical prediction and more. However, very few models have been developed to integrate both clinical and imaging data, despite that in routine practice clinicians rely on EMR to provide context in medical imaging interpretation. In this study, we developed and compared different multimodal fusion model architectures that are capable of utilizing both pixel data from volumetric Computed Tomography Pulmonary Angiography scans and clinical patient data from the EMR to automatically classify Pulmonary Embolism (PE) cases. The best performing multimodality model is a late fusion model that achieves an AUROC of 0.947 [95% CI: 0.946-0.948] on the entire held-out test set, outperforming imaging-only and EMR-only single modality models.

Indexed as

Electronic Health RecordsNeural Networks, ComputerTomography, X-Ray ComputedClinical Decision-MakingDisease ManagementHumansImage Interpretation, Computer-AssistedImage Processing, Computer-AssistedMachine LearningPulmonary EmbolismSensitivity and SpecificityWorkflow

Identifiers

PMID33335111
PMCPMC7746687

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.