ReviewNPJ microgravity2020
Reviving lower body negative pressure as a countermeasure to prevent pathological vascular and ocular changes in microgravity.
Review in NPJ microgravity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Introducing the Concept of Exercise Holidays for Human Spaceflight - What Can We Learn From the Recovery of Bed Rest Passive Control Groups.Frontiers in physiology · 2022Pooled it
- Sex-based differences in central and cerebral hemodynamic responses to lower body negative pressure (LBNP): an experimental study.European journal of applied physiology · 2026Article
- The physiology of survival: Space.Experimental physiology · 2026Article
- Physical exercise protects cardiovascular fitness in long-term spaceflight: what have we learned?Science China. Life sciences · 2026Review
- Guidelines for use of the random positioning machine as a reduced-gravity analog.Scientific reports · 2026Article
- Ocular health in outer space and beyond gravity: A minireview.World journal of clinical cases · 2026Review
- A multifactorial, evidence-based analysis of pathophysiology in Spaceflight Associated Neuro-Ocular Syndrome (SANS).Eye (London, England) · 2025Review
- Artificial gravity as a potential countermeasure for Spaceflight Associated Neuro-Ocular Syndrome.Eye (London, England) · 2024Article
- Systematic review of the effectiveness of standalone passive countermeasures on microgravity-induced physiologic deconditioning.NPJ microgravity · 2024Review
- Linking cerebral hemodynamics and ocular microgravity-induced alterations through an in silico-in vivo head-down tilt framework.NPJ microgravity · 2024Article
- Systematic review of the use of ultrasound for venous assessment and venous thrombosis screening in spaceflight.NPJ microgravity · 2024Article
- Spaceflight associated neuro-ocular syndrome: proposed pathogenesis, terrestrial analogues, and emerging countermeasures.The British journal of ophthalmology · 2023Review
- Space habitats for bioengineering and surgical repair: addressing the requirement for reconstructive and research tissues during deep-space missions.NPJ microgravity · 2023Review
- Review
- Segmental Tissue Resistance of Healthy Young Adults during Four Hours of 6-Degree Head-Down-Tilt Positioning.Sensors (Basel, Switzerland) · 2023Article
- Pathophysiology, risk, diagnosis, and management of venous thrombosis in space: where are we now?NPJ microgravity · 2023Review
- Effects of exercise countermeasures on multisystem function in long duration spaceflight astronauts.NPJ microgravity · 2023Article
- Cardiovascular, Lymphatic, and Ocular Health in Space.Life (Basel, Switzerland) · 2022Review
- Head-mounted digital metamorphopsia suppression as a countermeasure for macular-related visual distortions for prolonged spaceflight missions and terrestrial health.Wearable technologies · 2022Article
- Future research directions to identify risks and mitigation strategies for neurostructural, ocular, and behavioral changes induced by human spaceflight: A NASA-ESA expert group consensus report.Frontiers in neural circuits · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mitigation of spaceflight-related pathologies such as spaceflight-associated neuro-ocular syndrome (SANS) and the recently discovered risk of venous thrombosis must happen before deep space exploration can occur. Lower body negative pressure (LBNP) can simulate gravitational stress during spaceflight that is likely to counteract SANS and venous thrombosis, but the ideal dose and method of delivery have yet to be determined. We undertook a review of current LBNP literature and conducted a gap analysis to determine the steps needed to adapt LBNP for in-flight use. We found that to use LBNP in flight, it must be adapted to long time duration/low pressure use that should be compatible with crew activities. A lack of understanding of the etiology of the pathologies that LBNP can counteract hinders the application of LBNP as a countermeasure during spaceflight. Future research should aim at filling the knowledge gaps outlined in this review.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.