Evidence map›Paper›PMID 33335067›Full record

ArticleJournal of cell science2021

Mutational inactivation of Apc in the intestinal epithelia compromises cellular organisation.

Helena Rannikmae, Samantha Peel, Simon Barry, Takao Senda, Marc de la Roche

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cell science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Helena RannikmaeDepartment of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK.ORCID 0000-0001-5803-6688
Samantha PeelDiscovery Science, BioPharmaceuticals R&D, AstraZeneca, Cambridge CB4 0WG, UK.
Simon BarryBioscience, Oncology R&D, AstraZeneca, Cambridge CB2 0RE, UK.
Takao SendaDepartment of Anatomy, Graduate School of Medicine, Gifu University, Gifu 501-1194, Japan.
Marc de la RocheDepartment of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK mad58@cam.ac.uk.ORCID 0000-0002-3757-082X
AstraZeneca (United Kingdom) · GBUniversity of Cambridge · GBGifu University · JP

Funding

Wellcome TrustWellcome Trust RG79465
6 · The paper itself

Abstract

The adenomatous polyposis coli (Apc) protein regulates diverse effector pathways essential for tissue homeostasis. Truncating oncogenic mutations in Apc removing its Wnt pathway and microtubule regulatory domains drives intestinal epithelia tumorigenesis. Exuberant cell proliferation is one well-established consequence of oncogenic Wnt pathway activity; however, the contribution of other deregulated molecular circuits to tumorigenesis has not been fully examined. Using

Indexed as

Adenomatous Polyposis Coli ProteinWnt Signaling PathwayCarcinogenesisCell ProliferationHumansIntestinal MucosaMutationAdenomatous Polyposis Coli ProteinAPC protein, humanAdenomatous polyposis coli, APCIntestinal epitheliaMicrotubule cytoskeletonOrganoidsWnt pathway

Identifiers

PMID33335067
PMCPMC7860127
OpenAlexW3110806014

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.