Trial reportThe European respiratory journal2021
A randomised controlled trial of the effect of a connected inhaler system on medication adherence in uncontrolled asthmatic patients.
Trial report in The European respiratory journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 4 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- Systematic Review of Electronic Monitoring to Increase Medication Adherence in Children With Asthma.Pediatric pulmonology · 2025Pooled it
- Remote monitoring in asthma: a systematic review.European respiratory review : an official journal of the European Respiratory Society · 2025Pooled it
- Characterisation of digital therapeutic clinical trials: a systematic review with natural language processing.The Lancet. Digital health · 2024Pooled it
- Digital interventions to improve adherence to maintenance medication in asthma.The Cochrane database of systematic reviews · 2022Pooled it
- Harnessing Machine Learning and Electronic Health Record Data to Improve Asthma Management.Current allergy and asthma reports · 2026Review
- Guided Inhalation via Electronic Monitoring in Children With Uncontrolled Asthma (the IMAGINE Study): Randomized Controlled Trial.JMIR pediatrics and parenting · 2025Article
- Digitally mapping the asthma journey-from diagnosis to remission.EClinicalMedicine · 2025Review
- Evaluating digital adherence support in asthma: the ADITION non-interventional study.ERJ open research · 2025Article
- Review
- Validation of an AI-Powered Smart Dry Powder Inhaler (RS01X) for Asthma and COPD in a Clinical Setting.International journal of chronic obstructive pulmonary disease · 2025Article
- Unlocking Better Asthma Control: A Narrative Review of Adherence to Asthma Therapy and Innovative Monitoring Solutions.Journal of clinical medicine · 2024Review
- Tele-Monitoring Applications in Respiratory Allergy.Journal of clinical medicine · 2024Review
- A Review of Sensor-Based Interventions for Supporting Patient Adherence to Inhalation Therapy.Patient preference and adherence · 2024Review
- Why the role of mHealth in allergy diagnosis and treatment adherence cannot be overlooked.Clinical and translational allergy · 2023Review
- Budget impact analysis of a digital monitoring platform for COPD.Cost effectiveness and resource allocation : C/E · 2023Article
- Mobile Health for Asthma.CHEST pulmonary · 2023Review
- Anticipated barriers and facilitators for implementing smart inhalers in asthma medication adherence management.NPJ primary care respiratory medicine · 2023Article
- Retrospective assessment of a collaborative digital asthma program for Medicaid-enrolled children in southwest Detroit: reductions in short-acting beta-agonist (SABA) medication use.Asthma research and practice · 2023Article
- Clinical Impact of Electronic Monitoring Devices of Inhalers in Adults with Asthma or COPD: A Systematic Review and Meta-Analysis.Pharmaceuticals (Basel, Switzerland) · 2023Review
- The emerging role of digital health in the management of asthma.Therapeutic advances in chronic disease · 2023Review
Corrections and comments
- Commented on by
Authors and funding
13 authors at 7 institutions in 5 countries.
Funding
Abstract
Suboptimal adherence to maintenance therapy contributes to poor asthma control and exacerbations. This study evaluated the effect of different elements of a connected inhaler system (CIS), comprising clip-on inhaler sensors, a patient-facing app and a healthcare professional (HCP) dashboard, on adherence to asthma maintenance therapy.This was an open-label, parallel-group, 6-month, randomised controlled trial in adults with uncontrolled asthma (asthma control test (ACT) score less than 20) on fixed-dose inhaled corticosteroids/long-acting β-agonist maintenance therapy (n=437). All subjects received fluticasone furoate/vilanterol ELLIPTA dry-powder inhalers for maintenance and salbutamol/albuterol metered-dose inhalers for rescue, with a sensor attached to each inhaler. Participants were randomised to one of five CIS study arms (allocation ratio 1:1:1:1:1) reflecting the recipient of the data feedback from the sensors, as follows: 1) maintenance use to participants and HCPs (n=87); 2) maintenance use to participants (n=88); 3) maintenance and rescue use to participants and HCPs (n=88); 4) maintenance and rescue use to participants (n=88); and 5) no feedback (control) (n=86).For the primary endpoint, observed mean±sd adherence to maintenance therapy over months 4-6 was 82.2±16.58% (n=83) in the "maintenance to participants and HCPs" arm and 70.8±27.30% (n=85) in the control arm. The adjusted least squares mean±se was 80.9±3.19% and 69.0±3.19%, respectively (study arm difference: 12.0%, 95% CI 5.2-18.8%; p<0.001). Adherence was also significantly greater in the other CIS arms
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.