Evidence map›Paper›PMID 33334920›Full record

ArticlePediatrics2021

Enrolling Minors in COVID-19 Vaccine Trials.

Kevin Mintz, E Jardas, Seema Shah, Christine Grady, Marion Danis, David Wendler

Abstract read
In one paragraph

Article in Pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Review
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  11. COVID-19 Management in Pediatrics.The journal for nurse practitioners : JNP · 2021
    Article
  12. Article
  13. Review
  14. Article
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kevin MintzDepartment of Bioethics, National Institutes of Health, Bethesda, Maryland.
E JardasDepartment of Bioethics, National Institutes of Health, Bethesda, Maryland.
Seema ShahAnn & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois; and.
Christine GradyDepartment of Bioethics, National Institutes of Health, Bethesda, Maryland.
Marion DanisDepartment of Bioethics, National Institutes of Health, Bethesda, Maryland.
David WendlerDepartment of Bioethics, National Institutes of Health, Bethesda, Maryland; dwendler@nih.gov.

Funding

Research and clinical care without informed consentZIACL010537 · CLC · CLINICAL CENTER · PI WENDLER, DAVID S · 2014 to 2025
$0k
6 · The paper itself

Abstract

It is widely agreed that an effective response to the coronavirus disease 2019 pandemic needs to include a vaccine that is safe and effective for minors. However, many current vaccine trials have no plans for when to enroll minors. Others have recently proposed enrolling minors as young as 12 years old. This lack of a systematic approach raises 2 concerns. Waiting too long to enroll minors could unjustly deny minors and their families the benefits of a vaccine and has the potential to delay an effective response to the pandemic by a year or longer. At the same time, enrolling minors too soon runs the risk of exposing them to excessive risks. With these concerns in mind, in the present article, we propose recommendations for when and how to enroll minors in vaccine trials for the coronavirus disease 2019.

Indexed as

COVID-19 VaccinesHealthy VolunteersMinorsAdolescentChildClinical Trials as TopicCommunity ParticipationCOVID-19Ethics Committees, ResearchHumansInformed Consent By MinorsPandemicsSARS-CoV-2COVID-19 Vaccines

Identifiers

PMID33334920
PMCPMC7919110

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.