Evidence map›Paper›PMID 33334874›Full record

ArticleDiabetes2021

Interphotoreceptor Retinol-Binding Protein Ameliorates Diabetes-Induced Retinal Dysfunction and Neurodegeneration Through Rhodopsin.

Jianglei Chen, Yan Shao, Temmy Sasore, Gennadiy Moiseyev, Kelu Zhou, Xiang Ma, Yanhong Du, Jian-Xing Ma

Open access · greenAbstract read
In one paragraph

Article in Diabetes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Resilience to diabetic retinopathy.Progress in retinal and eye research · 2024
    Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Critical Role of VEGF as a Direct Regulator of Photoreceptor Function.Advances in experimental medicine and biology · 2023
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Jianglei ChenDepartment of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK.
Yan ShaoDepartment of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK.
Temmy SasoreDepartment of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK.
Gennadiy MoiseyevDepartment of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK.
Kelu ZhouDepartment of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK.
Xiang MaDepartment of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK jian-xing-ma@ouhsc.edu.
Yanhong DuDepartment of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK jian-xing-ma@ouhsc.edu.
Jian-Xing MaDepartment of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK jian-xing-ma@ouhsc.edu.ORCID 0000-0001-8815-1716
University of Oklahoma Health Sciences Center · USTianjin Medical University Eye Hospital · CN

Funding

A new pathogenic mechanism for diabetic retinopathyR01EY019309 · NEI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Jian-Xing Jay Ma · 2009 to 2026
$6.1M
STUDIES OF RPE65R01EY012231 · NEI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI MA, JIAN-XING, MOISEYEV, GENNADIY · 1998 to 2021
$5.7M
Pilot Project ProgramP30GM122744 · NIGMS · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI LE, YUN ZHENG · 2017 to 2021
$5.5M
The wnt signaling pathway in choroidal neovascularizationR01EY018659 · NEI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI MA, JIAN-XING · 2009 to 2019
$3.7M
A Novel Pathogenic Pathway for Diabetic KeratopathyR01EY028949 · NEI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Dimitrios Karamichos, Jian-Xing Jay Ma · 2018 to 2026
$2.2M
NEI NIH HHS R01 EY012231NEI NIH HHS R01 EY018659NEI NIH HHS R01 EY019309NEI NIH HHS R01 EY028949NIGMS NIH HHS P30 GM122744
6 · The paper itself

Abstract

Patients with diabetes often experience visual defects before any retinal pathologies are detected. The molecular mechanism for the visual defects in early diabetes has not been elucidated. Our previous study reported that in early diabetic retinopathy (DR), rhodopsin levels were reduced due to impaired 11-

Indexed as

AnimalsApoptosisBlotting, WesternDiabetic RetinopathyEye ProteinsImmunohistochemistryInflammationIn Situ Nick-End LabelingMiceMice, TransgenicOxidative StressRetinal DegenerationRetinol-Binding ProteinsRetinol-Binding Proteins, InterstitialRhodopsinTomography, Optical CoherenceEye ProteinsRetinol-Binding ProteinsRetinol-Binding Proteins, InterstitialRhodopsin

Identifiers

PMID33334874
PMCPMC7897347
OpenAlexW3115365819

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.