Evidence map›Paper›PMID 33334834›Full record

ArticleBMJ open2020

Rehabilitation for ataxia study: protocol for a randomised controlled trial of an outpatient and supported home-based physiotherapy programme for people with hereditary cerebellar ataxia.

Sarah C Milne, Louise A Corben, Melissa Roberts, David Szmulewicz, J Burns, Anneke C Grobler, Shannon Williams, Jillian Chua, Christina Liang, Phillipa J Lamont and 9 more

Open access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
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  4. Review
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  8. Review
  9. Rehabilitation in patients with cerebellar ataxias.Arquivos de neuro-psiquiatria · 2022
    Article
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  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 6 institutions in 1 country.

Sarah C MilneBruce Lefroy Centre for Genetic Health Research, Murdoch Children's Research Institute, Parkville, Victoria, Australia.ORCID 0000-0002-9406-8609
Louise A CorbenBruce Lefroy Centre for Genetic Health Research, Murdoch Children's Research Institute, Parkville, Victoria, Australia.
Melissa RobertsBruce Lefroy Centre for Genetic Health Research, Murdoch Children's Research Institute, Parkville, Victoria, Australia.
David SzmulewiczBalance Disorders & Ataxia Service, Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria, Australia.
J BurnsUniversity of Sydney School of Health Sciences, Faculty of Medicine and Health & Children's Hospital at Westmead, Sydney, New South Wales, Australia.
Anneke C GroblerDepartment of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia.
Shannon WilliamsPhysiotherapy Department, Royal Perth Hospital, Perth, Western Australia, Australia.
Jillian ChuaPhysiotherapy Department, Ryde Hospital, Eastwood, New South Wales, Australia.
Christina LiangDepartment of Neurology, Royal North Shore Hospital, St Leonards, New South Wales, Australia.
Phillipa J LamontNeurogenetic Unit, Royal Perth Hospital, Perth, Western Australia, Australia.
Alison C GrootendorstMJD Foundation, Darwin, Northern Territory, Australia.
Libby MasseyMJD Foundation, Darwin, Northern Territory, Australia.
Carolyn SueDepartment of Neurology, Royal North Shore Hospital, St Leonards, New South Wales, Australia.
Kim DalzielMelbourne School of Population and Global Health, University of Melbourne, Parkville, Victoria, Australia.
Desiree LaGrappeMJD Foundation, Darwin, Northern Territory, Australia.
Liz WillisMJD Foundation, Darwin, Northern Territory, Australia.
Aleka FreijahRehabilitation Services, Royal Darwin and Palmerston Hospitals, Darwin, Northern Territory, Australia.
Paul GerkenRehabilitation Services, Royal Darwin and Palmerston Hospitals, Darwin, Northern Territory, Australia.
Martin B DelatyckiBruce Lefroy Centre for Genetic Health Research, Murdoch Children's Research Institute, Parkville, Victoria, Australia martin.delatycki@vcgs.org.au.
The University of Melbourne · AUThe University of Sydney · AURoyal Darwin Hospital · AURoyal Perth Hospital · AUFlorey Institute of Neuroscience and Mental Health · AUMonash Health · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionEmerging evidence indicates that rehabilitation can improve ataxia, mobility and independence in everyday activities in individuals with hereditary cerebellar ataxia. However, with the rarity of the genetic ataxias and known recruitment challenges in rehabilitation trials, most studies have been underpowered, non-randomised or non-controlled. This study will be the first, appropriately powered randomised controlled trial to examine the efficacy of an outpatient and home-based rehabilitation programme on improving motor function for individuals with hereditary cerebellar ataxia. METHODS AND ANALYSIS: This randomised, single-blind, parallel group trial will compare a 30-week rehabilitation programme to standard care in individuals with hereditary cerebellar ataxia. Eighty individuals with a hereditary cerebellar ataxia, aged 15 years and above, will be recruited. The rehabilitation programme will include 6 weeks of outpatient land and aquatic physiotherapy followed immediately by a 24- week home exercise programme supported with fortnightly physiotherapy sessions. Participants in the standard care group will be asked to continue their usual physical activity. The primary outcome will be the motor domain of the Functional Independence Measure. Secondary outcomes will measure the motor impairment related to ataxia, balance, quality of life and cost-effectiveness. Outcomes will be administered at baseline, 7 weeks, 18 weeks and 30 weeks by a physiotherapist blinded to group allocation. A repeated measures mixed-effects linear regression model will be used to analyse the effect of the treatment group for each of the dependent continuous variables. The primary efficacy analysis will follow the intention-to-treat principle. ETHICS AND DISSEMINATION: The study has been approved by the Monash Health Human Research Ethics Committee (HREC/18/MonH/418) and the Human Research Ethics Committee of the Northern Territory Department of Health and Menzies School of Health Research (2019/3503). Results will be published in peer-reviewed journals, presented at national and/or international conferences and disseminated to Australian ataxia support groups. TRIAL REGISTRATION NUMBER: ACTRN12618000908235.

Indexed as

Cerebellar AtaxiaOutpatientsPhysical Therapy ModalitiesQuality of LifeAdolescentAtaxiaAustraliaExercise TherapyHumansRandomized Controlled Trials as TopicSingle-Blind Methodneurologyneuromuscular diseaserehabilitation medicine

Identifiers

PMID33334834
PMCPMC7747606
OpenAlexW3112768009

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.