ArticleGenes & development2021
Conserved Gsx2/Ind homeodomain monomer versus homodimer DNA binding defines regulatory outcomes in flies and mice.
Article in Genes & development, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 34 citations in OpenAlex.
- An inducible system to study the regulatory functions of GSX2 in human lateral ganglionic eminence-like progenitors.Developmental biology · 2026Article
- A molecular, spatial and regulatory atlas of the Hydra vulgaris nervous system.Development (Cambridge, England) · 2025Article
- Novel Insights into Emx2 and Dmrta2 Cooperation during Cortex Development and Evidence for Dmrta2 Function in the Choroid Plexus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- The ALX4 dimer structure provides insight into how disease alleles impact function.Nature communications · 2025Article
- NOTCH, ERK, and SHH signaling respectively control the fate determination of cortical glia and olfactory bulb interneurons.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Modelling a pathological GSX2 variant that selectively alters DNA binding reveals hypomorphic mouse brain defects.Disease models & mechanisms · 2025Article
- Combinatorial transcription factor binding encodes cis-regulatory wiring of mouse forebrain GABAergic neurogenesis.Developmental cell · 2025Article
- Homeodomain Involvement in Nuclear HOX Protein Homo- and Heterodimerization.International journal of molecular sciences · 2025Article
- Cooperative Gsx2-DNA binding requires DNA bending and a novel Gsx2 homeodomain interface.Nucleic acids research · 2024Article
- DNA Conserved in Diverse Animals Since the Precambrian Controls Genes for Embryonic Development.Molecular biology and evolution · 2023Article
- Acquisition of neural fate by combination of BMP blockade and chromatin modification.iScience · 2023Article
- The CUT&RUN suspect list of problematic regions of the genome.Genome biology · 2023Article
- Prediction of cooperative homeodomain DNA binding sites from high-throughput-SELEX data.Nucleic acids research · 2023Article
- Gsx2, but not Gsx1, is necessary for early forebrain patterning and long-term survival in zebrafish.Developmental dynamics : an official publication of the American Association of Anatomists · 2023Article
- Prediction of Back-splicing sites for CircRNA formation based on convolutional neural networks.BMC genomics · 2022Article
- Developmental Origins of Human Cortical Oligodendrocytes and Astrocytes.Neuroscience bulletin · 2022Article
- Genetic Regulation of Vertebrate Forebrain Development by Homeobox Genes.Frontiers in neuroscience · 2022Review
- Molecular Characterization of HOXA2 and HOXA3 Binding Properties.Journal of developmental biology · 2021Article
- From Progenitors to Progeny: Shaping Striatal Circuit Development and Function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Review
- Decoding Cortical Glial Cell Development.Neuroscience bulletin · 2021Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
How homeodomain proteins gain sufficient specificity to control different cell fates has been a long-standing problem in developmental biology. The conserved Gsx homeodomain proteins regulate specific aspects of neural development in animals from flies to mammals, and yet they belong to a large transcription factor family that bind nearly identical DNA sequences in vitro. Here, we show that the mouse and fly Gsx factors unexpectedly gain DNA binding specificity by forming cooperative homodimers on precisely spaced and oriented DNA sites. High-resolution genomic binding assays revealed that Gsx2 binds both monomer and homodimer sites in the developing mouse ventral telencephalon. Importantly, reporter assays showed that Gsx2 mediates opposing outcomes in a DNA binding site-dependent manner: Monomer Gsx2 binding represses transcription, whereas homodimer binding stimulates gene expression. In
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.