ArticleGenes & development2021
A feed-forward regulatory loop in adipose tissue promotes signaling by the hepatokine FGF21.
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Article in Genes & development, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- The crucial role and mechanism of insulin resistance in metabolic disease.Frontiers in endocrinology · 2023Pooled it
- Glucose and lipopolysaccharide differentially regulate fibroblast growth factor 21 in healthy male human volunteers - A prospective cross-over trial.Journal of cellular and molecular medicine · 2022Trial
- Metabolic-inflammatory memory: the common pathological basis and therapeutic targets of metabolic syndrome.Reviews in endocrine & metabolic disorders · 2026Review
- Attack of the kinases: JNK signaling in metabolism.American journal of physiology. Regulatory, integrative and comparative physiology · 2026Review
- Mutually exclusive alternative pre-mRNA splicing promotes adaptive metabolic stress signaling by JNK.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- JNK1 mediates serine phosphorylation of STAT3 in response to fatty acids released by lipolysis.Journal of lipid research · 2026Article
- Insulin-sensitizing effects of fibroblast growth factor-21 in underfed sheep.Journal of animal science · 2025Article
- Targeting fibroblast growth factor (FGF)-21: a promising strategy for metabolic dysfunction-associated steatotic liver disease treatment.Frontiers in pharmacology · 2025Review
- Age of Cafeteria Diet Onset Influences Obesity Phenotype in Mice in a Sex-Specific Manner.International journal of molecular sciences · 2024Article
- New advances of adiponectin in regulating obesity and related metabolic syndromes.Journal of pharmaceutical analysis · 2024Review
- Exploring endocrine FGFs - structures, functions and biomedical applications.International journal of biochemistry and molecular biology · 2024Review
- Friend or foe for obesity: How hepatokines remodel adipose tissues and translational perspective.Genes & diseases · 2023Review
- Gene therapy targeting miR‑212‑3p exerts therapeutic effects on MAFLD similar to those of exercise.International journal of molecular medicine · 2023Article
- Phosphorylation of RXRα mediates the effect of JNK to suppress hepatic FGF21 expression and promote metabolic syndrome.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Critical Overview of Hepatic Factors That Link Non-Alcoholic Fatty Liver Disease and Acute Kidney Injury: Physiology and Therapeutic Implications.International journal of molecular sciences · 2022Review
- Article
- New developments in the biology of fibroblast growth factors.WIREs mechanisms of disease · 2022Review
- FGF21 Is Released During Increased Lipogenesis State Following Rapid-Onset Radioiodine-Induced Hypothyroidism.Frontiers in endocrinology · 2022Article
- Hepatic FGF21: Its Emerging Role in Inter-Organ Crosstalk and Cancers.International journal of biological sciences · 2022Review
- Cross-Talk Between Gut Microbiota and Adipose Tissues in Obesity and Related Metabolic Diseases.Frontiers in endocrinology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Myoung Sook HanProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.ORCID 0000-0002-7226-2590
Rachel J PerryDepartment of Internal Medicine, Yale School of Medicine, New Haven, Connecticut 06520, USA.ORCID 0000-0003-0748-8064
João-Paulo CamporezDepartment of Internal Medicine, Yale School of Medicine, New Haven, Connecticut 06520, USA.ORCID 0000-0003-3486-4301
Philipp E SchererTouchstone Diabetes Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.ORCID 0000-0003-0680-3392
Gerald I ShulmanDepartment of Internal Medicine, Yale School of Medicine, New Haven, Connecticut 06520, USA.ORCID 0000-0003-1529-5668
Guangping GaoHorae Gene Therapy Center, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.ORCID 0000-0003-0097-9012
Roger J DavisProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.ORCID 0000-0002-0130-1652
University of Massachusetts Chan Medical School · USYale University · USThe University of Texas Southwestern Medical Center · US
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MYale Diabetes Research CenterP30DK045735 · NIDDK · YALE UNIVERSITY · PI Richard A Flavell · 1993 to 2026
$44.0MYale Liver CenterP30DK034989 · NIDDK · YALE UNIVERSITY · PI YASUKO IWAKIRI · 1986 to 2026
$31.1MThe role of AgRP/Auga-ALK pathway in FGF21's brain action on agingP01AG051459 · NIA · YALE UNIVERSITY · PI VISHWA DEEP DIXIT · 2016 to 2026
$25.7MAdiponectin, A Protein Secreted From Adipose TissueR01DK055758 · NIDDK · YESHIVA UNIVERSITY · PI SCHERER, PHILIPP E · 2000 to 2024
$10.9MAdipose Tissue Metabolic Stress ResponsesR01DK112698 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI DAVIS, ROGER J. · 2017 to 2025
$4.4MMetabolic Stress SignalingR01DK107220 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI DAVIS, ROGER J. · 2016 to 2023
$3.6MMicrobiome origins and insulin regulatory responses of the short chain fatty acid acetateR01DK114793 · NIDDK · YALE UNIVERSITY · PI GOODMAN, ANDREW L, SHULMAN, GERALD I · 2018 to 2021
$2.4MGlucagon Regulation of Hepatic Mitochondrial Activity and Glucose Metabolism by InsP3R-1R01DK116774 · NIDDK · YALE UNIVERSITY · PI SHULMAN, GERALD I · 2018 to 2021
$1.7MPromotion of fatty liver disease by the ASK1 pathwayR01DK121545 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI DAVIS, ROGER J. · 2019 to 2021
$1.6MRegulation of tumor growth and metabolism by hyperinsulinemiaR00CA215315 · NCI · YALE UNIVERSITY · PI PERRY, RACHEL JAMISON · 2018 to 2020
$689kNCATS NIH HHS UL1 TR001863NCI NIH HHS R00 CA215315NIA NIH HHS P01 AG051459NIDDK NIH HHS P30 DK034989NIDDK NIH HHS P30 DK045735NIDDK NIH HHS R01 DK055758NIDDK NIH HHS R01 DK107220NIDDK NIH HHS R01 DK112698NIDDK NIH HHS R01 DK114793NIDDK NIH HHS R01 DK116774NIDDK NIH HHS R01 DK121545
Abstract
The cJun NH
Indexed as
AdipocytesAdiponectinAdipose TissueAnimalsAutocrine CommunicationEndocrine SystemEnergy MetabolismFeedback, PhysiologicalFibroblast Growth FactorsGene Expression RegulationHepatocytesInsulin ResistanceLiverMAP Kinase Kinase 4MAP Kinase Signaling SystemMiceAdiponectinfibroblast growth factor 21Fibroblast Growth FactorsMAP Kinase Kinase 4autocrineendocrineFGF21JNKorgan cross-talk
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What OpenQuestion holds
Textmetadata
LicenceCC BY-NC
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.