Evidence map›Paper›PMID 33334773›Full record

ArticleBMJ case reports2020

Reactivation of BCG inoculation site in a child with febrile exanthema of 3 days duration: an early indicator of incomplete Kawasaki disease.

Kimberley Ying Ying Lim, Mei Chien Chua, Natalie Woon Hui Tan, Suresh Chandran

Open access · greenAbstract readCase Reports
In one paragraph

Article in BMJ case reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Kimberley Ying Ying LimPaediatrics, National University Singapore Yong Loo Lin School of Medicine, Singapore.
Mei Chien ChuaDepartment of Neonatology, KK Women's and Children's Hospital, Singapore.
Natalie Woon Hui TanInfectious Disease Service, Department of Paediatrics, KK Women's and Children's Hospital, Singapore.
Suresh ChandranNeonatology, KK Women's and Children's Hospital, Singapore profschandran2019@gmail.com.ORCID http://orcid.org/0000-0001-5961-7441
KK Women's and Children's Hospital · SGNational University of Singapore · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aetiology of febrile exanthems in children is often difficult to distinguish clinically. A diagnosis of Kawasaki disease (KD) should be considered in infants with exanthematous fever. More perplexing is the increasing incidence of an atypical form of KD. Pathogenesis of KD remains unclear even though an aberrant response of the immune system to an unidentified pathogen is often hypothesised. A 30-fold increase in the incidence of KD in Italy during the SARS-CoV-2 pandemic suggests an immune response to a viral trigger. We report an infant clinically diagnosed with high probability as incomplete KD, who presented with reactivation of the BCG injection site even though fever with rash was only less than 3 days duration. Echocardiography confirmed coronary artery abnormalities and prompt treatment with intravenous immunoglobulin facilitated rapid recovery. Physicians should consider a diagnosis of KD if BCG site reactivation is noted in children presenting with febrile exanthema.

Indexed as

BCG VaccineExanthemaFevergamma-GlobulinsHumansImmunologic FactorsInfantMaleMucocutaneous Lymph Node SyndromeVaccinationBCG Vaccinegamma-GlobulinsImmunologic Factorscardiovascular systemimmunological products and vaccinesischaemic heart diseasemedical managementvaccination/immunisation

Identifiers

PMID33334773
PMCPMC7747535
OpenAlexW3112531536

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.