Evidence map›Paper›PMID 33334687›Full record

SynthesisPediatrics and neonatology2021

Characterization of neonates born to mothers with SARS-CoV-2 infection: Review and meta-analysis.

Vanessa Neef, Horst Buxmann, Holger F Rabenau, Kai Zacharowski, Florian J Raimann

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Pediatrics and neonatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
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  8. Review
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  12. Review
  13. Frontiers in nutrition · 2022
    Article
  14. Article
  15. Article
  16. Review
  17. Effects of the COVID pandemic on pregnancy outcomes.Best practice & research. Clinical obstetrics & gynaecology · 2021
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Vanessa NeefDepartment of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Goethe University Frankfurt, Germany.
Horst BuxmannCLinic for Children and Adolescents, Division for Neonatology, University Hospital Frankfurt, Goethe University Frankfurt, Germany.
Holger F RabenauInstitute for Medical Virology, University Hospital Frankfurt, Goethe University Frankfurt, Germany.
Kai ZacharowskiDepartment of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Goethe University Frankfurt, Germany.
Florian J RaimannDepartment of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Goethe University Frankfurt, Germany. Electronic address: Florian.Raimann@kgu.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Characterization of neonates born to mothers with SARS-CoV-2 infection has been partially carried out. There has been no systematic review providing a holistic neonatal presentation including possible vertical transmission. A systematic literature search was performed using PubMed, Google Scholar and Web of Science up to June, 6 2020. Studies on neonates born to mothers with SARS-CoV-2 infection were included. A binary random effect model was used for prevalence and 95% confidence interval. 32 studies involving 261 neonates were included in meta-analysis. Most neonates born to infected mothers did not show any clinical abnormalities (80.4%). Clinical features were dyspnea in 11 (42.3%) and fever in 9 newborns (19.1%). Of 261 neonates, 120 neonates were tested for infection, of whom 12 (10.0%) tested positive. Swabs from placenta, cord blood and vaginal secretion were negative. Neonates are mostly non affected by the mother's SARS-CoV-2 infection. The risk of vertical transmission is low.

Indexed as

Infectious Disease Transmission, VerticalPregnancy Complications, InfectiousSARS-CoV-2COVID-19FemaleHumansInfant, NewbornMalePregnancyCOVID-19infantneonatenewbornSARS-CoV-2

Identifiers

PMID33334687
PMCPMC7585378

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.