Evidence map›Paper›PMID 33334652›Full record

ArticleEuropean neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology2021

Dissecting the role of CB

Xia Li, Briana J Hempel, Hong-Ju Yang, Xiao Han, Guo-Hua Bi, Eliot L Gardner, Zheng-Xiong Xi

Open access · greenAbstract read
In one paragraph

Article in European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 30 citations in OpenAlex.

  1. Cannabinoid CB1 receptor and mu-opioid receptor interaction: new insights from conditional knockout mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
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  15. Receptor mechanisms underlying the CNS effects of cannabinoids: CBAdvances in pharmacology (San Diego, Calif.) · 2022
    Article
  16. Cannabinoid CBNeuropharmacology · 2021
    Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Xia LiMolecular Targets and Medication Discovery Branch, National Institute on Drug Abuse, Intramural Research Program, 251 Bayview Blvd, NIDA IRP, BRC Suite 200, Baltimore, MD 21224, USA; Department of Psychiatry, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
Briana J HempelMolecular Targets and Medication Discovery Branch, National Institute on Drug Abuse, Intramural Research Program, 251 Bayview Blvd, NIDA IRP, BRC Suite 200, Baltimore, MD 21224, USA.
Hong-Ju YangMolecular Targets and Medication Discovery Branch, National Institute on Drug Abuse, Intramural Research Program, 251 Bayview Blvd, NIDA IRP, BRC Suite 200, Baltimore, MD 21224, USA.
Xiao HanMolecular Targets and Medication Discovery Branch, National Institute on Drug Abuse, Intramural Research Program, 251 Bayview Blvd, NIDA IRP, BRC Suite 200, Baltimore, MD 21224, USA.
Guo-Hua BiMolecular Targets and Medication Discovery Branch, National Institute on Drug Abuse, Intramural Research Program, 251 Bayview Blvd, NIDA IRP, BRC Suite 200, Baltimore, MD 21224, USA.
Eliot L GardnerMolecular Targets and Medication Discovery Branch, National Institute on Drug Abuse, Intramural Research Program, 251 Bayview Blvd, NIDA IRP, BRC Suite 200, Baltimore, MD 21224, USA.
Zheng-Xiong XiMolecular Targets and Medication Discovery Branch, National Institute on Drug Abuse, Intramural Research Program, 251 Bayview Blvd, NIDA IRP, BRC Suite 200, Baltimore, MD 21224, USA. Electronic address: zxi@mail.nih.gov.
National Institute on Drug Abuse · USUniversity of California, San Diego · US

Funding

Vaccine and Drug Combination Therapy for Human CancersZIABC010661 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI HODGE, JAMES · 2009 to 2025
$11.2M
Basic brain mechanisms underlying drug addiction, craving, and relapseZIADA000478 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI GARDNER, ELIOT · 2009 to 2023
$7.9M
Role of reactive oxygen species and the microbiome in intestinal barrier homeostasisZIAAI001216 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI HOLLAND, STEVEN · 2016 to 2025
$4.1M
Cannabinoid CB1 and CB2 receptors and drug abuseZIGDA000633 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI XI, ZHENG-XIONG · 2020 to 2022
$3.6M
Intramural NIH HHS Z99 DA999999Intramural NIH HHS ZIG DA000633
6 · The paper itself

Abstract

Cannabinoids produce both rewarding and aversive effects in humans and experimental animals. However, the mechanisms underlying these conflicting findings are unclear. Here we examined the potential involvement of CB

Indexed as

CannabinoidsCannabisAnimalsDronabinolMiceMice, KnockoutRatsReceptor, Cannabinoid, CB1Receptor, Cannabinoid, CB2Receptors, CannabinoidRewardCannabinoidsDronabinolReceptor, Cannabinoid, CB1Receptor, Cannabinoid, CB2Receptors, CannabinoidAversionCB(1) receptorCB(2) receptorDopamineRewardΔ(9)-Tetrahydrocannabinol (Δ(9)-THC)

Identifiers

PMID33334652
PMCPMC7854511
OpenAlexW3112986801

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.