SynthesisBiological psychiatry2021
The Influence of Cannabis and Nicotine Co-use on Neuromaturation: A Systematic Review of Adolescent and Young Adult Studies.
Synthesis in Biological psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Context-dependent attention and memory outcomes resulting from combined prenatal THC and nicotine exposure following chronic stress.Pharmacology, biochemistry, and behavior · 2026Article
- The Cannabis Research Image Database (CRESIDA): A standardized and validated image set for studying cannabis cue reactivity.Addiction (Abingdon, England) · 2026Article
- Longitudinal neurocognitive trajectories in a large cohort of youth who use cannabis: combining self-report and toxicology.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Impact of Preoperative Marijuana Use on Functional Recovery and Complications After Spinopelvic Fusion in Adult Spinal Deformity.Neurosurgery practice · 2026Article
- Network analysis of caffeine use disorder, withdrawal symptoms, and psychiatric symptoms.BMC psychiatry · 2025Article
- Age of onset of nicotine use and severity of nicotine addiction symptoms are associated with hippocampal volume in late adolescents and emerging adults.Frontiers in adolescent medicine · 2025Article
- A preliminary investigation of physical and mental health features of cannabis & nicotine co-use among adolescents and young adults by sex.Addictive behaviors · 2024Article
- Classification of patterns of tobacco and cannabis co-use based on temporal proximity: A qualitative study among young adults.Addictive behaviors · 2024Article
- Neurite Orientation Dispersion and Density Imaging (NODDI) of Brain Microstructure in Adolescent Cannabis and Nicotine Use.Behavioral sciences (Basel, Switzerland) · 2024Article
- The Combined Effects of Nicotine and Cannabis on Cortical Thickness Estimates in Adolescents and Emerging Adults.Brain sciences · 2024Article
- Distress about social problems and tobacco and cannabis use outcomes among young adults in Los Angeles County.Preventive medicine · 2024Article
- First Used Nicotine/Cannabis Product and Associated Outcomes in Late Adolescents.Substance use & misuse · 2024Article
- Prevalence and correlates of past 30-day dual-vaping of nicotine and cannabis among adolescents in five New England states.Drug and alcohol dependence · 2024Article
- Review
- Cannabis and Nicotine Dual Use among Sexual Minority Individuals: Relations to Cannabis Use and Negative Affect.Substance use & misuse · 2023Article
- E-cigarettes may serve as a gateway to conventional cigarettes and other addictive drugs.Advances in drug and alcohol research · 2023Review
- Initiation of Moderately Frequent Cannabis use in Adolescence and Young Adulthood is Associated with Declines in Verbal Learning and Memory: A Longitudinal Comparison of Pre- versus Post-Initiation Cognitive Performance.Journal of the International Neuropsychological Society : JINS · 2021Article
- Tobacco and Nervous System Development and Function-New Findings 2015-2020.Brain sciences · 2021Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Accumulating evidence suggests that the use of cannabis and nicotine and tobacco-related products (NTPs) during the adolescent years has harmful effects on the developing brain. Yet, few studies have focused on the developing brain as it relates to the co-administration of cannabis and NTPs, despite the high prevalence rates of co-use in adolescence. This review aims to synthesize the existing literature on neurocognitive, structural neuroimaging, and functional neuroimaging outcomes associated with cannabis and NTP co-use. A systematic search of peer-reviewed articles resulted in a pool of 1107 articles. Inclusion criteria were 1) data-based study; 2) age range of 13 to 35 years or, for preclinical studies, nonadult subjects; 3) cannabis and NTP group jointly considered; and 4) neurocognitive, structural neuroimaging, or functional neuroimaging as an outcome measure. Twelve studies met inclusion criteria. Consistent with the literature, cannabis and nicotine were found to have independent effects on cognition. The available research on the co-use of cannabis and NTPs demonstrates a potential nicotine-related masking effect on cognitive deficits associated with cannabis use, yet there is little research on co-use and associations with neuroimaging indices. In neuroimaging studies, there is preliminary evidence for hippocampal volume differences in co-users and a lack of evidence for co-use differences related to nucleus accumbens activity during reward processing. Notably, no structural neuroimaging studies were found to examine the combined effects of nicotine and cannabis in adolescent-only populations. Further research, including longitudinal studies, is warranted to investigate the influence of cannabis and NTP co-use on maturation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.