ArticleReproductive health2020
Association of parity with birthweight and neonatal death in five sites: The Global Network's Maternal Newborn Health Registry study.
Article in Reproductive health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24 citing papers in PubMed, 43 citations in OpenAlex.
- Pre-pregnancy BMI and gestational weight gain: determinants of birthweight of term neonates in central Sri Lanka, a low-middle-income country.BMC public health · 2026Article
- Predicting abnormal birth weight and identifying associated factors using machine learning in the Hararghe Health and Demographic Surveillance System, Ethiopia.BMC public health · 2026Article
- Interpretable prediction of neonatal mortality and its key predictors using machine learning and SHAP analysis.BMC medical informatics and decision making · 2026Article
- Modelling the Cost-Effectiveness of a Placental Malaria Vaccine in Sub-Saharan Africa.Vaccines · 2026Article
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- Neonatal mortality and survival of low-birth-weight infants at hospitals in indonesia, a multi center study.Scientific reports · 2025Article
- Assessing ambient air pollution's effects on birth outcomes: a Scottish IVF cohort study (2010 -2018).Environmental health : a global access science source · 2025Article
- Maternal parity modifies the association of birthweight polygenic score with fetal growth.Scientific reports · 2025Article
- Prediction of birthweight with early and mid-pregnancy antenatal markers utilising machine learning and explainable artificial intelligence.Scientific reports · 2025Article
- Analysis of the in-hospital mortality in the tertiary referral department of neonatology and neonatal intensive care.Scientific reports · 2025Article
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- Risk factors for neonatal admission from the beginning of pregnancy in Northeast Spain.Journal of paediatrics and child health · 2025Observational
- Exploring parental factors influencing low birth weight on the 2022 CDC natality dataset.BMC medical informatics and decision making · 2024Article
- Maternal hemoglobin drop in multiple pregnancy is associated with higher gestational age at birth and birthweight.Acta obstetricia et gynecologica Scandinavica · 2024Article
- The prevalence of low birth weight and its associated maternal factors among women of reproductive age who gave birth to live babies within five years preceding the survey in Tanzania: an analysis of data from the 2015-16 Tanzania Demographic and Health Survey and Malaria Indicators Survey.BMC pregnancy and childbirth · 2024Article
- The smaller firstborn: exploring the association of parity and fetal growth.Archives of gynecology and obstetrics · 2024Article
- Article
- Altitude Modifies the Effect of Parity on Birth Weight/Length Ratio: A Study Comprising 2,057,702 Newborns between 1984 and 2020 in Austria.Life (Basel, Switzerland) · 2023Article
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Authors and funding
18 authors at 12 institutions in 5 countries.
Funding
Abstract
backgroundNulliparity has been associated with lower birth weight (BW) and other adverse pregnancy outcomes, with most of the data coming from high-income countries. In this study, we examined birth weight for gestational age z-scores and neonatal (28-day) mortality in a large prospective cohort of women dated by first trimester ultrasound from multiple sites in low and middle-income countries.
methodsPregnant women were recruited during the first trimester of pregnancy and followed through 6 weeks postpartum from Maternal Newborn Health Registry (MNHR) sites in the Democratic Republic of Congo (DRC), Guatemala, Belagavi and Nagpur, India, and Pakistan from 2017 and 2018. Data related to the pregnancy and its outcomes were collected prospectively. First trimester ultrasound was used for determination of gestational age; (BW) was obtained in grams within 48 h of delivery and later transformed to weight for age z-scores (WAZ) adjusted for gestational age using the INTERGROWTH-21st standards.
results15,121 women were eligible and included. Infants of nulliparous women had lower mean BWs (males: 2676 gr, females: 2587 gr, total: 2634 gr) and gestational age adjusted weight for age z-scores (males: - 0.73, females: - 0.77, total: - 0.75,) than women with one or more previous pregnancies. The largest differences were between zero and one previous pregnancies among female infants. The associations of parity with BW and z-scores remained even after adjustment for maternal age, maternal height, maternal education, antenatal care visits, hypertensive disorders, and socioeconomic status. Nulliparous women also had a significantly higher < 28-day neonatal mortality rate (27.7 per 1,000 live births) than parous women (17.2 and 20.7 for parity of 1-3 and ≥ 4 respectively). Risk of preterm birth was higher among women with ≥ 4 previous pregnancies (15.5%) compared to 11.3% for the nulliparous group and 11.8% for women with one to three previous pregnancies (p = 0.0072).
conclusionsIn this large sample from diverse settings, nulliparity was independently associated with both lower BW and WAZ scores as well as higher neonatal mortality compared to multiparity.
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