Evidence map›Paper›PMID 33334356›Full record

ArticleReproductive health2020

Rates and risk factors for preterm birth and low birthweight in the global network sites in six low- and low middle-income countries.

Yamini V Pusdekar, Archana B Patel, Kunal G Kurhe, Savita R Bhargav, Vanessa Thorsten, Ana Garces, Robert L Goldenberg, Shivaprasad S Goudar, Sarah Saleem, Fabian Esamai and 11 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Reproductive health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01073475 (Global Network for Women's and Children's Health Research Maternal Newborn Health Registry), which is not on this map. Cited by 85 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed, 2 pooled it
16.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01073475 recruitingnot on this map

Global Network for Women's and Children's Health Research Maternal Newborn Health Registry

TypeobservationalSponsorNICHD Global Network for Women's and Children's HealthRan2008 to 2030Enrolled950,000ConditionsPregnancy Outcome Trends in Low-resource Geographic AreasArmsThere is no intervention associated with the parent MNHR study. For the MNHR COVID sub-study, participants will be asked to provide a blood specimen at or near delivery.
3 · Its place in the literature

Who cites it

85 citing papers in PubMed, 2 syntheses or guidelines pooled it, 130 citations in OpenAlex.

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  7. [Neuropsychological development in late preterm infants: the potential role of parent-child interaction].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026
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25 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 15 institutions in 6 countries.

Yamini V PusdekarLata Medical Research Foundation, Nagpur, India. dryaminipusdekar27@gmail.com.ORCID http://orcid.org/0000-0001-9706-4905
Archana B PatelLata Medical Research Foundation, Nagpur, India.
Kunal G KurheLata Medical Research Foundation, Nagpur, India.
Savita R BhargavLata Medical Research Foundation, Nagpur, India.
Vanessa ThorstenRTI International, Durham, NC, USA.
Ana GarcesInstituto de Nutrición de Centroamérica y Panamá, Guatemala City, Guatemala.
Robert L GoldenbergDepartment of Obstetrics and Gynecology, Columbia University School of Medicine, New York, NY, USA.
Shivaprasad S GoudarKLE Academy Higher Education and Research J N Medical College , Belagavi, Karnataka, India.
Sarah SaleemAga Khan University, Karachi, Pakistan.
Fabian EsamaiMoi University School of Medicine, Eldoret, Kenya.
Elwyn ChombaUniversity Teaching Hospital, Lusaka, Zambia.
Melissa BausermanUniversity of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Carl L BoseUniversity of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Edward A LiechtyIndiana School of Medicine, University of Indiana, Indianapolis, IN, USA.
Nancy F KrebsUniversity of Colorado School of Medicine, Denver, CO, USA.
Richard J DermanThomas Jefferson University, Philadelphia, USA.
Waldemar A CarloUniversity of Alabama at Birmingham, Birmingham, AL, USA.
Marion Koso-ThomasEunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA.
Tracy L NolenRTI International, Durham, NC, USA.
Elizabeth M McClureRTI International, Durham, NC, USA.
Patricia L HibberdSchool of Public Health, Boston University, Boston, MA, USA.
Lata Medical Research Foundation · INRTI International · USUniversity of North Carolina at Chapel Hill · USAga Khan University · PKBoston University · USColumbia University · USEunice Kennedy Shriver National Institute of Child Health and Human Development · USIndiana University – Purdue University Indianapolis · USInstitute of Nutrition of Central America and Panama · GTKLE University · INMoi University · KEThomas Jefferson University · USUniversity of Alabama at Birmingham · USUniversity of Colorado Denver · USUniversity Teaching Hospital · ZM

Funding

The University of North Carolina-Kinshasa School of Public Health Research Partnership in the Democratic Republic of Congo; a Model for Improving Women'sand Children's Health Through ResearchUG1HD076465 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MELISSA SCHWEIKHART BAUSERMAN · 2018 to 2026
$5.6M
Boston University/Lata Medical Research Foundation Global Network for Women's Children's Health Research UnitUG1HD078439 · NICHD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Patricia L Hibberd · 2018 to 2026
$5.5M
TJU-JNMC Global Network for Women's & Children's Health Research UnitUG1HD076457 · NICHD · THOMAS JEFFERSON UNIVERSITY · PI RICHARD J DERMAN · 2018 to 2026
$5.5M
Nutrition-specific interventions to improve long-term maternal-child health outcomesUG1HD076474 · NICHD · UNIVERSITY OF COLORADO DENVER · PI Edwin Jose Asturias, NANCY F KREBS · 2018 to 2026
$5.4M
Columbia University/Aga Khan University Global Network Research UnitUG1HD078438 · NICHD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ROBERT L GOLDENBERG · 2018 to 2026
$5.1M
Global Network for Women's and Children's Health ResearchUG1HD076461 · NICHD · INDIANA UNIVERSITY INDIANAPOLIS · PI BUCHER, SHERRI LYNN, SZYLD, EDGARDO GABRIEL · 2018 to 2023
$3.2M
A Strategy to Reduce Stunting of Growth in Early Infancy: a Global Network StudyU10HD076465 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BOSE, CARL · 2013 to 2017
$2.9M
NICHD NIH HHS U10 HD076465NICHD NIH HHS UG1 HD076457NICHD NIH HHS UG1 HD076461NICHD NIH HHS UG1 HD076465NICHD NIH HHS UG1 HD076474NICHD NIH HHS UG1 HD078438NICHD NIH HHS UG1 HD078439
6 · The paper itself

Abstract

backgroundPreterm birth continues to be a major public health problem contributing to 75% of the neonatal mortality worldwide. Low birth weight (LBW) is an important but imperfect surrogate for prematurity when accurate assessment of gestational age is not possible. While there is overlap between preterm birth and LBW newborns, those that are both premature and LBW are at the highest risk of adverse neonatal outcomes. Understanding the epidemiology of preterm birth and LBW is important for prevention and improved care for at risk newborns, but in many countries, data are sparse and incomplete.

methodsWe conducted data analyses using the Global Network's (GN) population-based registry of pregnant women and their babies in rural communities in six low- and middle-income countries (Democratic Republic of Congo, Kenya, Zambia, Guatemala, India and Pakistan). We analyzed data from January 2014 to December 2018. Trained study staff enrolled all pregnant women in the study catchment area as early as possible during pregnancy and conducted follow-up visits shortly after delivery and at 42 days after delivery. We analyzed the rates of preterm birth, LBW and the combination of preterm birth and LBW and studied risk factors associated with these outcomes across the GN sites.

resultsA total of 272,192 live births were included in the analysis. The overall preterm birth rate was 12.6% (ranging from 8.6% in Belagavi, India to 21.8% in the Pakistani site). The overall LBW rate was 13.6% (ranging from 2.7% in the Kenyan site to 21.4% in the Pakistani site). The overall rate of both preterm birth and LBW was 5.5% (ranging from 1.2% in the Kenyan site to 11.0% in the Pakistani site). Risk factors associated with preterm birth, LBW and the combination were similar across sites and included nulliparity [RR - 1.27 (95% CI 1.21-1.33)], maternal age under 20 [RR 1.41 (95% CI 1.32-1.49)] years, severe antenatal hemorrhage [RR 5.18 95% CI 4.44-6.04)], hypertensive disorders [RR 2.74 (95% CI - 1.21-1.33], and 1-3 antenatal visits versus four or more [RR 1.68 (95% CI 1.55-1.83)].

conclusionsPreterm birth, LBW and their combination continue to be common public health problems at some of the GN sites, particularly among young, nulliparous women who have received limited antenatal care services. Trial registration The identifier of the Maternal and Newborn Health Registry at ClinicalTrials.gov is NCT01073475.

trial registrationThe identifier of the Maternal and Newborn Health Registry at ClinicalTrials.gov is NCT01073475.

Indexed as

Infant, Low Birth WeightBirth WeightDeveloping CountriesFemaleHumansInfantInfant, NewbornPregnancyPremature BirthRisk FactorsAfricaGlobal networkGuatemalaIndiaLow and middle-income countriesLow birth weightPretermRisk factors

Identifiers

PMID33334356
PMCPMC7745351
OpenAlexW3113164131

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.