Evidence map›Paper›PMID 33334325›Full record

ArticleBMC medical genetics2020

A non-synonymous variant rs12614 of complement factor B associated with risk of chronic hepatitis B in a Korean population.

Jung Yeon Seo, Joong-Gon Shin, Byeong Ju Youn, Suhg Namgoong, Hyun Sub Cheong, Lyoung Hyo Kim, Ji On Kim, Hyoung Doo Shin, Yoon Jun Kim

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC medical genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 78% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Jung Yeon SeoCurrent address: Department of Core Technology, R&D Center, LG Household & Healthcare (LG H&H), Seoul, 07795, South Korea.
Joong-Gon ShinCurrent address: Department of Core Technology, R&D Center, LG Household & Healthcare (LG H&H), Seoul, 07795, South Korea.
Byeong Ju YounDepartment of Life Science, Sogang University, Seoul, 04107, Republic of Korea.
Suhg NamgoongDepartment of Life Science, Sogang University, Seoul, 04107, Republic of Korea.
Hyun Sub CheongDepartment of Genetic Epidemiology, SNP Genetics Inc., Seoul, 04107, Republic of Korea.
Lyoung Hyo KimDepartment of Genetic Epidemiology, SNP Genetics Inc., Seoul, 04107, Republic of Korea.
Ji On KimResearch Institute for Basic Science, Sogang University, Seoul, 04107, Republic of Korea.
Hyoung Doo ShinDepartment of Life Science, Sogang University, Seoul, 04107, Republic of Korea. hdshin@sogang.ac.kr.ORCID 0000-0003-1732-7838
Yoon Jun KimDepartment of Internal Medicine and Liver Research Institute, Seoul National University, 103 Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea. yoonjun@snu.ac.kr.
Sogang University · KRSNP Genetics (South Korea) · KRSeoul National University · KR

Funding

Ministry of Education 2017R1D1A1B03030763Ministry of Education, Science and Technology NRF-2015R1A2A1A15053987Ministry of Health and Welfare HI16C1074Yuhan Corporation 800-20170050
6 · The paper itself

Abstract

backgroundHepatitis B is known to cause several forms of liver diseases including chronic hepatitis B (CHB), and hepatocellular carcinoma. Previous genome-wide association study of CHB risk has demonstrated that rs12614 of complement factor B (CFB) was significantly associated with CHB risk. In this study, fine-mapping study of previously reported GWAS single nucleotide polymorphism (SNP; CFB rs12614) was performed to validate genetic effect of rs12614 on CHB susceptibility and identify possible additional causal variants around rs12614 in a Korean population. This association study was conducted in order to identify genetic effects of CFB single nucleotide polymorphisms (SNPs) and to identify additional independent CHB susceptible causal markers within a Korean population.

methodsA total of 10 CFB genetic polymorphisms were selected and genotyped in 1716 study subjects comprised of 955 CHB patients and 761 population controls.

resultsA non-synonymous variant, rs12614 (Arg32Trp) in exon2 of CFB, had significant associations with risk of CHB (odds ratio = 0.43, P = 5.91 × 10

conclusionsrs12614 showed significant genetic effect on CHB risk within the Korean population. As such rs12614 may be used as a possible causal genetic variant for CHB susceptibility.

Indexed as

ExonsGenetic Predisposition to DiseasePolymorphism, Single NucleotideAdultCase-Control StudiesComplement Factor BGene ExpressionHepatitis B, ChronicHumansLinkage DisequilibriumMaleMiddle AgedOdds RatioRepublic of KoreaRiskComplement Factor BCFBGenetic risk scoresHepatitis BKorean populationLiver disease

Identifiers

PMID33334325
PMCPMC7745368
OpenAlexW3113360953

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.