Evidence map›Paper›PMID 33334271›Full record

ArticleTechnology in cancer research & treatment

The Effects of Hydrogen Peroxide and/or Radiation on the Survival of Clinically Relevant Radioresistant Cells.

Yoshikazu Kuwahara, Kazuo Tomita, Mehryar Habibi Roudkenar, Amaneh Mohammadi Roushandeh, Yusuke Urushihara, Kento Igarashi, Taisuke Nagasawa, Akihiro Kurimasa, Manabu Fukumoto, Tomoaki Sato

Open access · goldAbstract read
In one paragraph

Article in Technology in cancer research & treatment. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Yoshikazu KuwaharaDivision of Radiation Biology and Medicine, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Fukumuro, Miyagino, Sendai, Miyagi, Japan.
Kazuo TomitaDepartment of Applied Pharmacology, Graduate School of Medical and Dental Sciences, Kagoshima University, Sakuragaoka, Kagoshima, Japan.ORCID 0000-0003-1266-7948
Mehryar Habibi RoudkenarDepartment of Applied Pharmacology, Graduate School of Medical and Dental Sciences, Kagoshima University, Sakuragaoka, Kagoshima, Japan.
Amaneh Mohammadi RoushandehDepartment of Applied Pharmacology, Graduate School of Medical and Dental Sciences, Kagoshima University, Sakuragaoka, Kagoshima, Japan.
Yusuke UrushiharaDepartment of Radiation Biology, Tohoku University School of Medicine, Aoba, Sendai, Miyagi, Japan.
Kento IgarashiDepartment of Applied Pharmacology, Graduate School of Medical and Dental Sciences, Kagoshima University, Sakuragaoka, Kagoshima, Japan.
Taisuke NagasawaDepartment of Applied Pharmacology, Graduate School of Medical and Dental Sciences, Kagoshima University, Sakuragaoka, Kagoshima, Japan.
Akihiro KurimasaDivision of Radiation Biology and Medicine, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Fukumuro, Miyagino, Sendai, Miyagi, Japan.
Manabu FukumotoRIKEN, Center for Advanced Intelligence Project, Chuo-ku, Tokyo, Japan.
Tomoaki SatoDepartment of Applied Pharmacology, Graduate School of Medical and Dental Sciences, Kagoshima University, Sakuragaoka, Kagoshima, Japan.
Kagoshima University · JPRIKEN Center for Advanced Intelligence Project · JPTohoku Medical and Pharmaceutical University Hospital · JPTohoku University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRadiation therapy is a highly cost-effective treatment for cancer, but the existence of radio-resistant cells remains the most critical obstacle in radiotherapy. We have been established clinically relevant radioresistant (CRR) cell lines by exposure to a stepwise increase of fractionated X-rays. We are trying to overcome the radio-resistance by analyzing the properties of these cells. In this study, we tried to evaluate the effects of hydrogen peroxide (H MATERIALS AND

methodsWe used human cancer cell lines derived from hepatoblastoma (HepG2), oral squamous cell carcinoma (SAS), and cervical cancer (HeLa). We established HepG2, SAS, and HeLa CRR cells and HepG2, SAS, and HeLa H

resultsCRR cells were resistant to H

conclusionFractionated X-ray exposure induces H

Indexed as

Radiation, IonizingCell DeathCell Line, TumorCell SurvivalDose-Response Relationship, DrugDose-Response Relationship, RadiationHumansHydrogen PeroxideRadiation ToleranceReactive Oxygen SpeciesX-RaysHydrogen PeroxideReactive Oxygen Speciescell deathclinically relevant radioresistant cellsH2O2 resistant cellsradiation therapyreactive oxygen species

Identifiers

PMID33334271
PMCPMC7758870
OpenAlexW3112580698

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.