Evidence map›Paper›PMID 33334192›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2021

Novel positive allosteric modulators of A

Elisabetta Barresi, Chiara Giacomelli, Laura Marchetti, Emma Baglini, Silvia Salerno, Giovanni Greco, Federico Da Settimo, Claudia Martini, Maria Letizia Trincavelli, Sabrina Taliani

Open access · goldAbstract read
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. APurinergic signalling · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Elisabetta BarresiDepartment of Pharmacy, University of Pisa, Pisa, Italy.ORCID https://orcid.org/0000-0002-9814-7195
Chiara GiacomelliDepartment of Pharmacy, University of Pisa, Pisa, Italy.ORCID https://orcid.org/0000-0002-6244-602X
Laura MarchettiDepartment of Pharmacy, University of Pisa, Pisa, Italy.ORCID https://orcid.org/0000-0002-2110-9481
Emma BagliniDepartment of Pharmacy, University of Pisa, Pisa, Italy.ORCID https://orcid.org/0000-0002-8378-4052
Silvia SalernoDepartment of Pharmacy, University of Pisa, Pisa, Italy.ORCID https://orcid.org/0000-0002-6072-4698
Giovanni GrecoDepartment of Pharmacy, University of Naples "Federico II", Naples, Italy.ORCID https://orcid.org/0000-0002-4632-4620
Federico Da SettimoDepartment of Pharmacy, University of Pisa, Pisa, Italy.ORCID https://orcid.org/0000-0002-7897-7917
Claudia MartiniDepartment of Pharmacy, University of Pisa, Pisa, Italy.ORCID https://orcid.org/0000-0001-9379-3027
Maria Letizia TrincavelliDepartment of Pharmacy, University of Pisa, Pisa, Italy.ORCID https://orcid.org/0000-0001-8124-977X
Sabrina TalianiDepartment of Pharmacy, University of Pisa, Pisa, Italy.ORCID https://orcid.org/0000-0001-8675-939X
University of Pisa · ITUniversity of Naples Federico II · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Small-molecules acting as positive allosteric modulators (PAMs) of the A

Indexed as

Allosteric RegulationBone RegenerationCell DifferentiationCells, CulturedDose-Response Relationship, DrugHumansIndolesMesenchymal Stem CellsMolecular StructureReceptor, Adenosine A2BStructure-Activity RelationshipIndolesReceptor, Adenosine A2BA2B adenosine receptorallosteric modulatorsBAY60-6583bone formationmesenchymal stem cell

Identifiers

PMID33334192
PMCPMC7751416
OpenAlexW3117282943

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.