Evidence map›Paper›PMID 33334123›Full record

ArticleCirculation research2021

JNK2, a Newly-Identified SERCA2 Enhancer, Augments an Arrhythmic [Ca

Jiajie Yan, Dan J Bare, Jaime DeSantiago, Weiwei Zhao, Yiming Mei, Zhenhui Chen, Kenneth Ginsburg, R John Solaro, Beata M Wolska, Donald M Bers and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 2 pooled it
4.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.

  1. Guideline
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  3. Article
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  5. Differential effects of semaglutide and colchicine on atrial remodeling in rats with reduced ejection fraction after myocardial infarction.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Article
  6. Review
  7. Review
  8. Stress-Induced calcium mishandling in cardiac (Patho)physiology.Cellular and molecular life sciences : CMLS · 2025
    Review
  9. Review
  10. The role of JNK signaling pathway in organ fibrosis.Journal of advanced research · 2025
    Review
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  13. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 4 countries.

Jiajie YanPhysiology and Biophysics, Rush University Medical Center, Chicago, IL (J.Y., D.J.B., J.D., W.Z., Y.M., X.A.).
Dan J BarePhysiology and Biophysics, Rush University Medical Center, Chicago, IL (J.Y., D.J.B., J.D., W.Z., Y.M., X.A.).
Jaime DeSantiagoPhysiology and Biophysics, Rush University Medical Center, Chicago, IL (J.Y., D.J.B., J.D., W.Z., Y.M., X.A.).
Weiwei ZhaoPhysiology and Biophysics, Rush University Medical Center, Chicago, IL (J.Y., D.J.B., J.D., W.Z., Y.M., X.A.).
Yiming MeiPhysiology and Biophysics, Rush University Medical Center, Chicago, IL (J.Y., D.J.B., J.D., W.Z., Y.M., X.A.).
Zhenhui ChenMedicine, Indiana University, Indianapolis (Z.C.).
Kenneth GinsburgPharmacology, University of California Davis (K.G., D.M.B.).
R John SolaroPhysiology (R.J.S., B.M.W.), University of Illinois at Chicago.
Beata M WolskaPhysiology (R.J.S., B.M.W.), University of Illinois at Chicago.
Donald M BersPharmacology, University of California Davis (K.G., D.M.B.).
S R Wayne ChenPhysiology and Pharmacology, Libin Cardiovascular Institute, University of Calgary, Canada (S.R.W.C.).
Xun AiPhysiology and Biophysics, Rush University Medical Center, Chicago, IL (J.Y., D.J.B., J.D., W.Z., Y.M., X.A.).
Rush University Medical Center · USUniversity of Illinois Chicago · USDonaldson (United States) · USIndiana University – Purdue University Indianapolis · USKorean Society of Ginseng · KRLibin Cardiovascular Institute of Alberta · CA

Funding

Sarcomeric Modifications and Progressive Cardiac MaladaptationP01HL062426 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DE TOMBE, PIETER P. · 2000 to 2020
$42.4M
Project 3 (Mercola)P01HL141084 · NHLBI · STANFORD UNIVERSITY · PI Joseph C. Wu · 2019 to 2026
$21.1M
CaMKII activation and regulation in adult cardiac myocytesR01HL142282 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BERS, DONALD M, BOSSUYT, JULIE B · 2018 to 2025
$5.4M
The Stress Response Kinase JNK and Alcohol Evoked Atrial FibrillationR01AA024769 · NIAAA · OHIO STATE UNIVERSITY · PI AI, XUN, CHEN, SUI RONG WAYNE · 2017 to 2021
$3.3M
Heart-platelet crosstalk: JNK, AF, and thrombogenesisR01HL146744 · NHLBI · RUSH UNIVERSITY MEDICAL CENTER · PI Xun Ai, Yuchi Han · 2019 to 2026
$3.2M
Atrial and blood JNK in Postoperative AFR01HL168728 · NHLBI · OHIO STATE UNIVERSITY · PI Xun Ai · 2023 to 2026
$2.7M
JNK Suppression of Connexin43 Enhances Atrial Fibrillation in Aged AtriaR01HL113640 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AI, XUN · 2012 to 2015
$1.5M
NHLBI NIH HHS P01 HL062426NHLBI NIH HHS P01 HL141084NHLBI NIH HHS R01 HL113640NHLBI NIH HHS R01 HL142282NHLBI NIH HHS R01 HL146744NHLBI NIH HHS R01 HL168728NIAAA NIH HHS R01 AA024769
6 · The paper itself

Abstract

rationaleWe recently discovered pivotal contributions of stress kinase JNK2 (c-Jun N-terminal kinase isoform 2) in increased risk of atrial fibrillation through enhanced diastolic sarcoplasmic reticulum (SR) calcium (Ca

objectiveTo test the hypothesis that JNK2 increases SERCA2 activity SR Ca METHODS AND

resultsWe used confocal Ca

conclusionsWe have identified a novel JNK2-induced activation of SERCA2. The dual action of JNK2 in CaMKII-dependent arrhythmic SR Ca

Indexed as

Calcium SignalingAction PotentialsAnimalsArrhythmias, CardiacCalcium-Calmodulin-Dependent Protein Kinase Type 2Cells, CulturedHEK293 CellsHumansMaleMiceMice, Inbred C57BLMitogen-Activated Protein Kinase 9Myocytes, CardiacRabbitsRyanodine Receptor Calcium Release ChannelSarcoplasmic ReticulumAtp2a2 protein, mouseCalcium-Calmodulin-Dependent Protein Kinase Type 2Mitogen-Activated Protein Kinase 9Ryanodine Receptor Calcium Release ChannelSarcoplasmic Reticulum Calcium-Transporting ATPasesanimalsatrial fibrillationJNK mitogen-activated protein kinasesphosphorylationsarcoplasmic reticulum

Identifiers

PMID33334123
PMCPMC7897290
OpenAlexW3114238000

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.