Evidence map›Paper›PMID 33334036›Full record

ArticleJournal of clinical medicine2020

Associations between Clinical Symptoms and Degree of Ossification in Patients with Cervical Ossification of the Posterior Longitudinal Ligament: A Prospective Multi-Institutional Cross-Sectional Study.

Takashi Hirai, Toshitaka Yoshii, Shuta Ushio, Jun Hashimoto, Kanji Mori, Satoshi Maki, Keiichi Katsumi, Narihito Nagoshi, Kazuhiro Takeuchi, Takeo Furuya and 27 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Observational
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

37 authors at 19 institutions in 1 country.

Takashi HiraiDepartment of Orthopedic Surgery, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.
Toshitaka YoshiiDepartment of Orthopedic Surgery, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.
Shuta UshioDepartment of Orthopedic Surgery, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.ORCID 0000-0001-5422-7655
Jun HashimotoDepartment of Orthopedic Surgery, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.
Kanji MoriJapanese Organization of the Study for Ossification of Spinal Ligament (JOSL), Tokyo 113-8510, Japan.
Satoshi MakiJapanese Organization of the Study for Ossification of Spinal Ligament (JOSL), Tokyo 113-8510, Japan.
Keiichi KatsumiJapanese Organization of the Study for Ossification of Spinal Ligament (JOSL), Tokyo 113-8510, Japan.ORCID 0000-0002-3997-3593
Narihito NagoshiJapanese Organization of the Study for Ossification of Spinal Ligament (JOSL), Tokyo 113-8510, Japan.
Kazuhiro TakeuchiJapanese Organization of the Study for Ossification of Spinal Ligament (JOSL), Tokyo 113-8510, Japan.
Takeo FuruyaJapanese Organization of the Study for Ossification of Spinal Ligament (JOSL), Tokyo 113-8510, Japan.
Kei WatanabeJapanese Organization of the Study for Ossification of Spinal Ligament (JOSL), Tokyo 113-8510, Japan.
Norihiro NishidaJapanese Organization of the Study for Ossification of Spinal Ligament (JOSL), Tokyo 113-8510, Japan.
Soraya NishimuraJapanese Organization of the Study for Ossification of Spinal Ligament (JOSL), Tokyo 113-8510, Japan.
Kota WatanabeJapanese Organization of the Study for Ossification of Spinal Ligament (JOSL), Tokyo 113-8510, Japan.ORCID 0000-0002-4830-4690
Takashi KaitoJapanese Organization of the Study for Ossification of Spinal Ligament (JOSL), Tokyo 113-8510, Japan.ORCID 0000-0003-4882-2997
Satoshi KatoJapanese Organization of the Study for Ossification of Spinal Ligament (JOSL), Tokyo 113-8510, Japan.ORCID 0000-0003-4762-5932
Katsuya NagashimaJapanese Organization of the Study for Ossification of Spinal Ligament (JOSL), Tokyo 113-8510, Japan.
Masao KodaJapanese Organization of the Study for Ossification of Spinal Ligament (JOSL), Tokyo 113-8510, Japan.
Kenyu ItoJapanese Organization of the Study for Ossification of Spinal Ligament (JOSL), Tokyo 113-8510, Japan.
Shiro ImagamaJapanese Organization of the Study for Ossification of Spinal Ligament (JOSL), Tokyo 113-8510, Japan.
Yuji MatsuokaJapanese Organization of the Study for Ossification of Spinal Ligament (JOSL), Tokyo 113-8510, Japan.
Kanichiro WadaJapanese Organization of the Study for Ossification of Spinal Ligament (JOSL), Tokyo 113-8510, Japan.
Atsushi KimuraJapanese Organization of the Study for Ossification of Spinal Ligament (JOSL), Tokyo 113-8510, Japan.ORCID 0000-0003-4948-1792
Tetsuro OhbaJapanese Organization of the Study for Ossification of Spinal Ligament (JOSL), Tokyo 113-8510, Japan.
Hiroyuki KatohJapanese Organization of the Study for Ossification of Spinal Ligament (JOSL), Tokyo 113-8510, Japan.ORCID 0000-0003-0046-3008
Masahiko WatanabeJapanese Organization of the Study for Ossification of Spinal Ligament (JOSL), Tokyo 113-8510, Japan.ORCID 0000-0001-9038-0446
Yukihiro MatsuyamaJapanese Organization of the Study for Ossification of Spinal Ligament (JOSL), Tokyo 113-8510, Japan.
Hiroshi OzawaJapanese Organization of the Study for Ossification of Spinal Ligament (JOSL), Tokyo 113-8510, Japan.ORCID 0000-0002-6991-0948
Hirotaka HaroJapanese Organization of the Study for Ossification of Spinal Ligament (JOSL), Tokyo 113-8510, Japan.ORCID 0000-0002-5630-9600
Katsushi TakeshitaJapanese Organization of the Study for Ossification of Spinal Ligament (JOSL), Tokyo 113-8510, Japan.
Morio MatsumotoJapanese Organization of the Study for Ossification of Spinal Ligament (JOSL), Tokyo 113-8510, Japan.
Masaya NakamuraJapanese Organization of the Study for Ossification of Spinal Ligament (JOSL), Tokyo 113-8510, Japan.
Masashi YamazakiJapanese Organization of the Study for Ossification of Spinal Ligament (JOSL), Tokyo 113-8510, Japan.ORCID 0000-0002-9293-3531
Masato YuasaDepartment of Orthopedic Surgery, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.
Hiroyuki InoseDepartment of Orthopedic Surgery, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.ORCID 0000-0003-4195-2545
Atsushi OkawaDepartment of Orthopedic Surgery, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.
Yoshiharu KawaguchiJapanese Organization of the Study for Ossification of Spinal Ligament (JOSL), Tokyo 113-8510, Japan.
Tokyo Medical and Dental University · JPKeio University · JPUniversity of Tsukuba · JPChiba University · JPJichi Medical University · JPNagoya University · JPTokai University · JPUniversity of Yamanashi · JPHamamatsu University School of Medicine · JPHirosaki University · JPKanazawa University · JPNational Hospital Organization · JPNiigata University Medical and Dental Hospital · JPShiga University of Medical Science · JPThe University of Osaka · JPTohoku Medical and Pharmaceutical University Hospital · JPTokyo Medical University · JPUniversity of Toyama · JPYamaguchi University · JP

Funding

Health and Labour Science Research grants 201610008BJapan Agency for Medical Research and Development 16ek0109136h0002
6 · The paper itself

Abstract

This study aimed to clarify whether ossification predisposition influences clinical symptoms including pain, restriction of activities of daily living, and quality of life in patients with cervical ossification of the posterior longitudinal ligament (OPLL). Cervical ossification predisposition potentially causes neurologic dysfunction, but the relationship between clinical symptoms and radiologic severity of OPLL has not yet been investigated. Data were prospectively collected from 16 institutions across Japan. We enrolled 239 patients with cervical OPLL. The primary outcomes were patient-reported outcomes, including visual analog scale (VAS) pain scores and other questionnaires. Whole-spine computed tomography images were obtained, and correlations were investigated between clinical symptoms and radiologic findings, including the distribution of OPLL, the sum of the levels where OPLL was present (OP-index), and the canal narrowing ratio (CNR) grade. The cervical OP-index was Grade 1 in 113 patients, Grade 2 in 90, and Grade 3 in 36. No significant correlations were found between radiologic outcomes and VAS pain scores. The cervical OP-index was associated with lower extremity function, social dysfunction, and locomotive function. The CNR grade was not correlated with clinical symptoms, but Grade 4 was associated with lower extremity dysfunction. Thickness and extension of ossified lesions may be associated with lower extremity dysfunction in cervical OPLL.

Indexed as

activities of daily livingcanal narrowing ratiocomputed tomographyOP-indexossification of the posterior longitudinal ligament (OPPL)painpatient-reported outcomesquality of lifespinal disorder

Identifiers

PMID33334036
PMCPMC7765525
OpenAlexW3111502240

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.