Evidence map›Paper›PMID 33334016›Full record

ArticleInternational journal of molecular sciences2020

Role of Genetic Variation in ABC Transporters in Breast Cancer Prognosis and Therapy Response.

Viktor Hlaváč, Radka Václavíková, Veronika Brynychová, Renata Koževnikovová, Katerina Kopečková, David Vrána, Jiří Gatěk, Pavel Souček

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Viktor HlaváčToxicogenomics Unit, National Institute of Public Health, 100 42 Prague, Czech Republic.ORCID 0000-0003-0695-0552
Radka VáclavíkováToxicogenomics Unit, National Institute of Public Health, 100 42 Prague, Czech Republic.
Veronika BrynychováToxicogenomics Unit, National Institute of Public Health, 100 42 Prague, Czech Republic.
Renata KoževnikovováDepartment of Oncosurgery, Medicon Services, 140 00 Prague, Czech Republic.
Katerina KopečkováDepartment of Oncology, Second Faculty of Medicine, Charles University and Motol University Hospital, 150 06 Prague, Czech Republic.
David VránaDepartment of Oncology, Medical School and Teaching Hospital, Palacky University, 779 00 Olomouc, Czech Republic.ORCID 0000-0002-7419-822X
Jiří GatěkDepartment of Surgery, EUC Hospital and University of Tomas Bata in Zlin, 760 01 Zlin, Czech Republic.
Pavel SoučekToxicogenomics Unit, National Institute of Public Health, 100 42 Prague, Czech Republic.ORCID 0000-0002-4294-6799
Charles University · CZMedicon · CZPalacký University Olomouc · CZTomas Bata University in Zlín · CZ

Funding

Czech Medical Council 17-28470ACzech Ministry of Education, Youth and Sports CZ.02.1.01/0.0/0.0/16_013/0001634Czech Science Foundation 19-03063SGrant Agency of Charles University UNCE/MED/006
6 · The paper itself

Abstract

Breast cancer is the most common cancer in women in the world. The role of germline genetic variability in ATP-binding cassette (ABC) transporters in cancer chemoresistance and prognosis still needs to be elucidated. We used next-generation sequencing to assess associations of germline variants in coding and regulatory sequences of all human ABC genes with response of the patients to the neoadjuvant cytotoxic chemotherapy and disease-free survival (

Indexed as

Biomarkers, TumorGenetic VariationAllelesAntineoplastic Combined Chemotherapy ProtocolsATP-Binding Cassette TransportersBreast NeoplasmsFemaleGene FrequencyGenotypeHigh-Throughput Nucleotide SequencingHumansKaplan-Meier EstimateNeoadjuvant TherapyPolymorphism, Single NucleotidePrognosisQuantitative Trait LociATP-Binding Cassette TransportersBiomarkers, TumorABC transporterbreast cancercompetitive allele-specific PCRdisease-free survivalnext-generation sequencingtherapy response

Identifiers

PMID33334016
PMCPMC7765380
OpenAlexW3112881343

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.