Evidence map›Paper›PMID 33333932›Full record

ReviewInternational journal of molecular sciences2020

Spliceosome Mutations in Uveal Melanoma.

Josephine Q N Nguyen, Wojtek Drabarek, Serdar Yavuzyigitoglu, Eva Medico Salsench, Robert M Verdijk, Nicole C Naus, Annelies de Klein, Emine Kiliç, Erwin Brosens

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 31 citations in OpenAlex.

  1. Review
  2. The Impact of Spliceosome Inhibition in SF3B1-Mutated Uveal Melanoma.Investigative ophthalmology & visual science · 2024
    Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Josephine Q N NguyenDepartment of Ophthalmology, Erasmus MC University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands.ORCID 0000-0002-6428-6226
Wojtek DrabarekDepartment of Ophthalmology, Erasmus MC University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands.
Serdar YavuzyigitogluDepartment of Ophthalmology, Erasmus MC University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands.
Eva Medico SalsenchDepartment of Clinical Genetics, Erasmus MC University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands.
Robert M VerdijkDepartment of Pathology, Section Ophthalmic Pathology, Erasmus MC Cancer Institute, Erasmus MC University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands.ORCID 0000-0003-1437-214X
Nicole C NausDepartment of Ophthalmology, Erasmus MC University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands.
Annelies de KleinDepartment of Clinical Genetics, Erasmus MC University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands.
Emine KiliçDepartment of Ophthalmology, Erasmus MC University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands.
Erwin BrosensDepartment of Clinical Genetics, Erasmus MC University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands.ORCID 0000-0001-8235-4010
Erasmus MC · NLLeiden University Medical Center · NL

Funding

Stichting Combined Ophthalmic Research Rotterdam CORR 5.2.0Stichting Steunfonds Uitzicht UZ-2018-4
6 · The paper itself

Abstract

Uveal melanoma (UM) is the most common primary intraocular malignancy of the eye. It has a high metastatic potential and mainly spreads to the liver. Genetics play a vital role in tumor classification and prognostication of UM metastatic disease. One of the driver genes mutated in metastasized UM is subunit 1 of splicing factor 3b (

Indexed as

MutationAmino Acid SubstitutionExonsGene FrequencyHumansMelanomaPhosphoproteinsRNA SplicingRNA Splicing FactorsSpliceosomesTelomereUveal MelanomaUveal NeoplasmsPhosphoproteinsRNA Splicing FactorsSF3B1 protein, humanchromosomesDNA repairepigeneticgeneticmetastatic diseasemutational analysisprognosistherapy

Identifiers

PMID33333932
PMCPMC7765440
OpenAlexW3110728830

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.