Evidence map›Paper›PMID 33333924›Full record

ArticleMolecules (Basel, Switzerland)2020

Synthesis and In Vitro Antiprotozoan Evaluation of 4-/8-Aminoquinoline-based Lactams and Tetrazoles.

Matshawandile Tukulula, Stefan Louw, Mathew Njoroge, Kelly Chibale

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Matshawandile TukululaSchool of Chemistry and Physics, University of KwaZulu Natal, Durban 4000, South Africa.ORCID 0000-0002-1844-3614
Stefan LouwDepartment of Chemistry, University of Cape Town, Rondebosch 7701, South Africa.ORCID 0000-0002-3122-8812
Mathew NjorogeDepartment of Chemistry, University of Cape Town, Rondebosch 7701, South Africa.ORCID 0000-0003-1276-2224
Kelly ChibaleDepartment of Chemistry, University of Cape Town, Rondebosch 7701, South Africa.

Funding

National Research Foundation 116282
6 · The paper itself

Abstract

A second generation of 4-aminoquinoline- and 8-aminoquinoline-based tetrazoles and lactams were synthesized via the Staudinger and Ugi multicomponent reactions. These compounds were subsequently evaluated in vitro for their potential antiplasmodium activity against a multidrug-resistant K1 strain and for their antitrypanosomal activity against a cultured

Indexed as

AminoquinolinesLactamsTetrazolesAntiprotozoal AgentsMolecular StructureTrypanosoma brucei rhodesiense4-aminoquinoline8-aminoquinolineAminoquinolinesAntiprotozoal AgentsLactamsTetrazoles4-aminoquinoline β-lactams8-aminoquinoline tetrazolesaqueous kinetic solubilityhuman African trypanosomiasis (HAT)Plasmodium falciparum chloroquine multidrug-resistant (K1) strain

Identifiers

PMID33333924
PMCPMC7765388

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.