Evidence map›Paper›PMID 33333914›Full record

ReviewNanomaterials (Basel, Switzerland)2020

Cyclodextrin-Based Functional Glyconanomaterials.

Gonzalo Rivero-Barbarroja, Juan Manuel Benito, Carmen Ortiz Mellet, José Manuel García Fernández

Registry-linked trialAbstract readReview
In one paragraph

Review in Nanomaterials (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04932265 (Dissolution and Pharmacokinetic of Ginsenosides Released From Cyclodextrin Based Chewable Tablets), which is not on this map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04932265 phase1suspendednot on this mapstarted 2021, after this paper: background citation

Dissolution and Pharmacokinetic of Ginsenosides Released From Cyclodextrin Based Chewable Tablets: a Comparative, Randomized, Crossover, Open-label Study in Healthy Human Subjects.

TypeinterventionalSponsorEuroPharma, Inc.Ran2021 to 2025Enrolled3ConditionsDrug AbsorptionArmsHRG80™ Red Ginseng, HRG80™ Red Ginseng + gamma cyclodextrin
3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Serine-/Cysteine-Based spJournal of medicinal chemistry · 2023
    Article
  8. Article
  9. Article
  10. Article
  11. Synthesis of spMolecules (Basel, Switzerland) · 2021
    Article
  12. Functional Glyconanomaterials.Nanomaterials (Basel, Switzerland) · 2021
    Article
  13. Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Gonzalo Rivero-BarbarrojaDepartment of Organic Chemistry, Faculty of Chemistry, University of Seville, 41012 Seville, Spain.ORCID 0000-0002-3124-9373
Juan Manuel BenitoInstituto de Investigaciones Químicas (IIQ), CSIC, Universidad de Sevilla, 41092 Sevilla, Spain.ORCID 0000-0002-9788-1507
Carmen Ortiz MelletDepartment of Organic Chemistry, Faculty of Chemistry, University of Seville, 41012 Seville, Spain.ORCID 0000-0002-7676-7721
José Manuel García FernándezInstituto de Investigaciones Químicas (IIQ), CSIC, Universidad de Sevilla, 41092 Sevilla, Spain.ORCID 0000-0002-6827-0387

Funding

Agencia Estatal de Investigación (AEI) -European Regional Development Funds -Ministerio de Ciencia e Innovación PID2019-105858RB-I00Ministerio de Ciencia, Innovación y Universidades RTI2018-097609-B-C21
6 · The paper itself

Abstract

Cyclodextrins (CDs) have long occupied a prominent position in most pharmaceutical laboratories as "off-the-shelve" tools to manipulate the pharmacokinetics of a broad range of active principles, due to their unique combination of biocompatibility and inclusion abilities. The development of precision chemical methods for their selective functionalization, in combination with "click" multiconjugation procedures, have further leveraged the nanoscaffold nature of these oligosaccharides, creating a direct link between the glyco and the nano worlds. CDs have greatly contributed to understand and exploit the interactions between multivalent glycodisplays and carbohydrate-binding proteins (lectins) and to improve the drug-loading and functional properties of nanomaterials through host-guest strategies. The whole range of capabilities can be enabled through self-assembly, template-assisted assembly or covalent connection of CD/glycan building blocks. This review discusses the advancements made in this field during the last decade and the amazing variety of functional glyconanomaterials empowered by the versatility of the CD component.

Indexed as

cyclodextrinsdrug deliverygene deliveryglyconanomaterialsglyconanoparticlesglycopolymersglycotargetingmultivalencyself-assemblysupramolecular nanomaterials

Identifiers

PMID33333914
PMCPMC7765426

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.