Evidence map›Paper›PMID 33333910›Full record

ArticleInternational journal of molecular sciences2020

A Plasma Proteomic Signature of Skeletal Muscle Mitochondrial Function.

Marta Zampino, Toshiko Tanaka, Ceereena Ubaida-Mohien, Giovanna Fantoni, Julián Candia, Richard D Semba, Luigi Ferrucci

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Observational
  3. Rejuvenation: Turning Back Time by Enhancing CISD2.International journal of molecular sciences · 2022
    Review
  4. Mitochondrial Dysfunctions and Potential Molecular Markers in Sport Horses.International journal of molecular sciences · 2022
    Review
  5. Article
  6. Musculoskeletal Aging and Sarcopenia in the Elderly.International journal of molecular sciences · 2022
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Marta ZampinoNational Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.ORCID 0000-0002-9381-3291
Toshiko TanakaNational Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.ORCID 0000-0002-4161-3829
Ceereena Ubaida-MohienNational Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
Giovanna FantoniClinical Research Core, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
Julián CandiaLaboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0001-5793-8989
Richard D SembaWilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Luigi FerrucciNational Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
National Institutes of Health · USJohns Hopkins University · US

Funding

Systemic rejuvenating factors and human aging phenotypes.R01AG057723 · NIA · JOHNS HOPKINS UNIVERSITY · PI SEMBA, RICHARD D · 2018 to 2022
$1.8M
NIA NIH HHS R01 AG057723NIH HHS R01 AG057723
6 · The paper itself

Abstract

Although mitochondrial dysfunction has been implicated in aging, physical function decline, and several age-related diseases, an accessible and affordable measure of mitochondrial health is still lacking. In this study we identified the proteomic signature of muscular mitochondrial oxidative capacity in plasma. In 165 adults, we analyzed the association between concentrations of plasma proteins, measured using the SOMAscan assay, and skeletal muscle maximal oxidative phosphorylation capacity assessed as post-exercise phosphocreatine recovery time constant (τ

Indexed as

AdultAgedAged, 80 and overEnergy MetabolismFemaleGene OntologyHumansInflammationMagnetic Resonance SpectroscopyMaleMiddle AgedMitochondriaMuscle, SkeletalOxidative StressPlasmaProteomeProteomeReactive Oxygen Speciesaptamersinflammationmitochondriaoxidative capacityphosphorous magnetic resonance spectroscopyplasmaproteomicsskeletal muscleSOMAscan

Identifiers

PMID33333910
PMCPMC7765442
OpenAlexW3112632065

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.