Evidence map›Paper›PMID 33333786›Full record

ArticleInternational journal of molecular sciences2020

p53 Is Regulated in a Biphasic Manner in Hypoxic Human Papillomavirus Type 16 (HPV16)-Positive Cervical Cancer Cells.

Linhan Zhuang, Regina Ly, Frank Rösl, Martina Niebler

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Linhan ZhuangDivision of Viral Transformation Mechanisms, Research Program Infection, Inflammation & Cancer, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 242, D-69120 Heidelberg, Germany.ORCID 0000-0002-1006-5911
Regina LyDivision of Viral Transformation Mechanisms, Research Program Infection, Inflammation & Cancer, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 242, D-69120 Heidelberg, Germany.
Frank RöslDivision of Viral Transformation Mechanisms, Research Program Infection, Inflammation & Cancer, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 242, D-69120 Heidelberg, Germany.
Martina NieblerDivision of Viral Transformation Mechanisms, Research Program Infection, Inflammation & Cancer, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 242, D-69120 Heidelberg, Germany.
German Cancer Research Center · DE

Funding

China Scholarship Council Graduate Student Fellowship not applicable
6 · The paper itself

Abstract

Although the effect of hypoxia on p53 in human papillomavirus (HPV)-positive cancer cells has been studied for decades, the impact of p53 regulation on downstream targets and cellular adaptation processes during different periods under hypoxia remains elusive. Here, we show that, despite continuous repression of HPV16

Indexed as

AutophagyCell HypoxiaCellular SenescenceDown-RegulationFemaleGene Expression Regulation, NeoplasticHuman papillomavirus 16HumansLysosomesMembrane ProteinsOncogene Proteins, ViralPapillomavirus InfectionsPromyelocytic Leukemia ProteinProto-Oncogene ProteinsRNA, Small InterferingTumor Suppressor Protein p53BNIP3 protein, humanDRAM1 protein, humanMembrane ProteinsOncogene Proteins, ViralPML protein, humanPromyelocytic Leukemia ProteinProto-Oncogene ProteinsRNA, Small InterferingTP53 protein, humanTumor Suppressor Protein p53Tumor Suppressor ProteinsYPEL3 protein, humanautophagycervical cancerhuman papillomavirushypoxiap53senescence

Identifiers

PMID33333786
PMCPMC7765197
OpenAlexW3110885972

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.