Trial reportNutrients2020
The Effects of an Infant Formula Enriched with Milk Fat Globule Membrane, Long-Chain Polyunsaturated Fatty Acids and Synbiotics on Child Behavior up to 2.5 Years Old: The COGNIS Study.
Trial report in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Bovine Milk Fat Globule Membrane Supplementation and Neurocognitive Development: A Systematic Review and Meta-Analysis.Nutrients · 2024Pooled it
- Trial
- Milk phospholipid-coated lipid droplets modulate the infant gut microbiota and metabolome influencing weight gain.Microbiome · 2025Trial
- Understanding the developmental trajectory of behavioral problems and subcortical structure morphometry in healthy children at 6 years old and long-term impact of early nutrition: the COGNIS study.Child and adolescent psychiatry and mental health · 2026Article
- Milk fat globule membrane in early-life nutrition: composition, production, and biological effects on infant immune maturation, intestinal development, neurocognitive function, and growth.Frontiers in nutrition · 2026Review
- Comparative Analysis of Breastfeeding and Infant Formulas: Short- and Long-Term Impacts on Infant Nutrition and Health.Food science & nutrition · 2025Review
- Milk Fat Globule Membranes for Mental Health across the Human Lifespan.Foods (Basel, Switzerland) · 2024Review
- A combination of phospholipids and long chain polyunsaturated fatty acids supports neurodevelopmental outcomes in infants: a randomized, double-blind, controlled clinical trial.Frontiers in nutrition · 2024Article
- Article
- Infant formula containing large, milk phospholipid-coated lipid droplets and dairy lipids affects cognitive performance at school age.Frontiers in nutrition · 2023Article
- Brain-immune-gut benefits with early life supplementation of milk fat globule membrane.JGH open : an open access journal of gastroenterology and hepatology · 2022Review
- Human Milk and Preterm Infant Brain Development: A Narrative Review.Clinical therapeutics · 2022Review
- Infant Formula Supplemented With Milk Fat Globule Membrane, Long-Chain Polyunsaturated Fatty Acids, and Synbiotics Is Associated With Neurocognitive Function and Brain Structure of Healthy Children Aged 6 Years: The COGNIS Study.Frontiers in nutrition · 2022Article
- Association study between hypothalamic functional connectivity, early nutrition, and glucose levels in healthy children aged 6 years: The COGNIS study follow-up.Frontiers in nutrition · 2022Article
- Milk Fat Globules: 2024 Updates.Newborn (Clarksville, Md.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 2 institutions in 2 countries.
Funding
Abstract
Although early life nutrition influences brain development and mental health, the long-term effects of supplemented infant formula on children´s behavior remain unclear. We analyzed the effects of a bioactive nutrients-enriched-infant formula on children's behavior up to 2.5 years, compared to a standard infant formula or breastfeeding. Current analysis involved 70 children who were fed a standard infant formula (SF,
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.