Evidence map›Paper›PMID 33333743›Full record

ReviewDiagnostics (Basel, Switzerland)2020

Next Generation Sequencing in Non-Small Cell Lung Cancer: Pitfalls and Opportunities.

Chiara Lazzari, Alessandra Bulotta, Maria Giulia Cangi, Gabriele Bucci, Lorenza Pecciarini, Silvia Bonfiglio, Vincenza Lorusso, Stefania Ippati, Gianluigi Arrigoni, Greta Grassini and 2 more

Abstract readReview
In one paragraph

Review in Diagnostics (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Observational
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Observational
  14. Article
  15. Case report:Frontiers in oncology · 2022
    Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Chiara LazzariDepartment of Oncology, IRCCS San Raffaele, 20132 Milan, Italy.
Alessandra BulottaDepartment of Oncology, IRCCS San Raffaele, 20132 Milan, Italy.
Maria Giulia CangiDepartment of Pathology, IRCCS San Raffaele, 20132 Milan, Italy.ORCID 0000-0002-9472-0935
Gabriele BucciCenter for Omics Science, IRCCS San Raffaele, 20132 Milan, Italy.ORCID 0000-0001-9838-7204
Lorenza PecciariniDepartment of Pathology, IRCCS San Raffaele, 20132 Milan, Italy.
Silvia BonfiglioCenter for Omics Science, IRCCS San Raffaele, 20132 Milan, Italy.
Vincenza LorussoDepartment of Oncology, IRCCS San Raffaele, 20132 Milan, Italy.ORCID 0000-0001-6989-4661
Stefania IppatiDepartment of Oncology, IRCCS San Raffaele, 20132 Milan, Italy.
Gianluigi ArrigoniDepartment of Pathology, IRCCS San Raffaele, 20132 Milan, Italy.
Greta GrassiniDepartment of Pathology, IRCCS San Raffaele, 20132 Milan, Italy.
Claudio DoglioniDepartment of Pathology, IRCCS San Raffaele, 20132 Milan, Italy.ORCID 0000-0002-4969-5216
Vanesa GregorcDepartment of Oncology, IRCCS San Raffaele, 20132 Milan, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lung cancer remains the first cause of cancer-related deaths worldwide. Thanks to the improvement in the knowledge of the biology of non-small cell lung cancer (NSCLC), patients' survival has significantly improved. A growing number of targetable molecular alterations have been identified. Next-generation sequencing (NGS) has become one of the methodologies entered in clinical practice and was recently recommended by the European society for medical oncology (ESMO) to perform a comprehensive molecular characterization in patients with cancer. The current review provides an overview of the clinical trials that have explored the impact of NGS in patients with cancer, its limits, and advantages.

Indexed as

molecular tumor boardnext-generation sequencingnon-small cell lung cancer

Identifiers

PMID33333743
PMCPMC7765222

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.