Evidence map›Paper›PMID 33333716›Full record

ArticlePharmaceuticals (Basel, Switzerland)2020

Non-Steroidal Anti-Inflammatory Drugs Increase Cisplatin, Paclitaxel, and Doxorubicin Efficacy against Human Cervix Cancer Cells.

Diana Xochiquetzal Robledo-Cadena, Juan Carlos Gallardo-Pérez, Víctor Dávila-Borja, Silvia Cecilia Pacheco-Velázquez, Javier Alejandro Belmont-Díaz, Stephen John Ralph, Betsy Alejandra Blanco-Carpintero, Rafael Moreno-Sánchez, Sara Rodríguez-Enríquez

Open access · goldAbstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 43 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Cancer-associated inflammation: pathophysiology and clinical significance.Journal of cancer research and clinical oncology · 2023
    Review
  10. Article
  11. Article
  12. Blockade of store-operated calcium entry sensitizes breast cancer cells to cisplatin therapy via modulating inflammatory response.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2023
    Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Diana Xochiquetzal Robledo-CadenaDepartamento de Bioquímica, Instituto Nacional de Cardiología, Mexico City 14080, Mexico.
Juan Carlos Gallardo-PérezDepartamento de Bioquímica, Instituto Nacional de Cardiología, Mexico City 14080, Mexico.
Víctor Dávila-BorjaLaboratorio de Oncología Experimental, Instituto Nacional de Pediatría, Mexico City 14080, Mexico.
Silvia Cecilia Pacheco-VelázquezDepartamento de Bioquímica, Instituto Nacional de Cardiología, Mexico City 14080, Mexico.
Javier Alejandro Belmont-DíazDepartamento de Bioquímica, Instituto Nacional de Cardiología, Mexico City 14080, Mexico.
Stephen John RalphMenzies Health Institute Queensland, School of Medical Science, Griffith University, Gold Coast, QLD 4222, Australia.
Betsy Alejandra Blanco-CarpinteroDepartamento de Bioquímica, Instituto Nacional de Cardiología, Mexico City 14080, Mexico.
Rafael Moreno-SánchezDepartamento de Bioquímica, Instituto Nacional de Cardiología, Mexico City 14080, Mexico.ORCID 0000-0002-9587-7184
Sara Rodríguez-EnríquezDepartamento de Bioquímica, Instituto Nacional de Cardiología, Mexico City 14080, Mexico.ORCID 0000-0002-0822-1233
Instituto Nacional de Cardiología · MXGriffith University · AUInstituto Nacional de Pediatria · MX

Funding

Consejo Nacional de Ciencia y Tecnologia Mexico, MEX 239930, 281428, 283144,464032
6 · The paper itself

Abstract

This study shows that the non-steroidal anti-inflammatory drug (NSAID) celecoxib and its non-cyclooxygenase-2 (COX2) analogue dimethylcelecoxib (DMC) exert a potent inhibitory effect on the growth of human cervix HeLa multi-cellular tumor spheroids (MCTS) when added either at the beginning ("preventive protocol"; IC

Indexed as

Bliss-type additivism modelcelecoxibdimethylcelecoxibdrug synergismHeLa cellsresistance index

Identifiers

PMID33333716
PMCPMC7765098
OpenAlexW3111298012

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.