ArticleAge and ageing2021
Consumption of dietary nuts in midlife and risk of cognitive impairment in late-life: the Singapore Chinese Health Study.
Article in Age and ageing, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Nutrition and Healthy Ageing in Asia: A Systematic Review.Nutrients · 2023Pooled it
- The effects of nuts intake on cognitive and executive function in obese children: a randomized clinical trial.Journal of health, population, and nutrition · 2025Trial
- Review
- Dietary habits and successful aging in Chinese older adults: a cross-sectional analysis of the CLHLS.Archives of public health = Archives belges de sante publique · 2025Article
- A Network Analysis of Food Intake and Cognitive Function in Older Adults with Multimorbidity: A National Cross-Sectional Study.Nutrients · 2025Article
- Nut consumption is associated with a lower risk of all-cause dementia in adults: a community-based cohort study from the UK Biobank.GeroScience · 2025Article
- Association between nutrition and cognition in a multi-ethnic cohort from Singapore.European journal of nutrition · 2023Article
- Higher versus lower nut consumption and changes in cognitive performance over two years in a population at risk of cognitive decline: a cohort study.The American journal of clinical nutrition · 2023Article
- Impact of Nut Consumption on Cognition across the Lifespan.Nutrients · 2023Review
- Dietary Diversity and Mild Cognitive Impairment in Middle-Aged and Older Chinese People: A Cross-Sectional Study.Journal of Alzheimer's disease reports · 2023Article
- Beneficial Effects of Nut Consumption on Cognitive Function Among Elderly: Findings From a 6-Year Cohort Study.Frontiers in aging neuroscience · 2022Article
- Nuts: Natural Pleiotropic Nutraceuticals.Nutrients · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundevidence from prospective studies investigating the association between consumption of nuts in midlife and risk of cognitive impairment in late life is limited.
methodsthis study analysed data from 16,737 participants in a population-based cohort, the Singapore Chinese Health Study. Intake of nuts was assessed using a validated food-frequency questionnaire at baseline (1993-1998), when participants were 45-74 years old (mean age = 53.5 years). Cognitive function was tested using the Singapore modified Mini-Mental State Examination during the third follow-up visit (2014-2016), when participants were 61-96 years old (mean age = 73.2 years). Cognitive impairment was defined using education-specific cut-off points. Logistic regression models were used to estimate the odds ratio (OR) and the 95% confidence interval (CI) for the association between intake and risk of cognitive impairment.
resultscognitive impairment was identified in 2,397 (14.3%) participants. Compared with those who consumed <1 serving/month of nuts, participants who consumed 1-3 servings/month, 1 serving/week and ≥2 servings/week had 12% (95% CI 2-20%), 19% (95% CI 4-31%) and 21% (2-36%) lower risk of cognitive impairment, respectively (P-trend = 0.01). Further adjustment for intake of unsaturated fatty acids attenuated the association to non-significance. Mediation analysis showed that the 50.8% of the association between nuts and risk of cognitive impairment was mediated by the intake of total unsaturated fatty acids (P < 0.001).
conclusionhigher intake of nuts in midlife was related to a lower risk of cognitive impairment in late life, which was partly mediated by unsaturated fatty acids.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.