Evidence map›Paper›PMID 33333447›Full record

ArticleBioorganic & medicinal chemistry2021

Synthesis, characterization, in vitro SAR study, and preliminary in vivo toxicity evaluation of naphthylmethyl substituted bis-imidazolium salts.

Marie R Southerland, Michael A DeBord, Nicholas A Johnson, Steven R Crabtree, Nicolas E Alexander, Michael L Stromyer, Patrick O Wagers, Matthew J Panzner, Chrys Wesdemiotis, Leah P Shriver and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic & medicinal chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Marie R SoutherlandDepartment of Chemistry, The University of Akron, Akron, OH 44325-3601, USA.
Michael A DeBordDepartment of Chemistry, The University of Akron, Akron, OH 44325-3601, USA.
Nicholas A JohnsonDepartment of Chemistry, Ashland University, 401 College Ave., Ashland, OH 44805, USA.
Steven R CrabtreeDepartment of Chemistry, The University of Akron, Akron, OH 44325-3601, USA.
Nicolas E AlexanderDepartment of Chemistry, The University of Akron, Akron, OH 44325-3601, USA.
Michael L StromyerDepartment of Chemistry, The University of Akron, Akron, OH 44325-3601, USA.
Patrick O WagersDepartment of Chemistry, The University of Akron, Akron, OH 44325-3601, USA.
Matthew J PanznerDepartment of Chemistry, The University of Akron, Akron, OH 44325-3601, USA.
Chrys WesdemiotisDepartment of Chemistry, The University of Akron, Akron, OH 44325-3601, USA.
Leah P ShriverDepartment of Chemistry, The University of Akron, Akron, OH 44325-3601, USA.
Claire A TessierDepartment of Chemistry, The University of Akron, Akron, OH 44325-3601, USA.
Wiley J YoungsDepartment of Chemistry, The University of Akron, Akron, OH 44325-3601, USA. Electronic address: youngs@uakron.edu.

Funding

ADHESIN-BASED NANOTHERAPEUTICS IN URINARY TRACT INFECTIONR01DK082546 · NIDDK · WASHINGTON UNIVERSITY · PI HUNSTAD, DAVID · 2010 to 2014
$1.6M
Ag(111) Carbeneporphyrinoids as RadiopharmaceuticalsR15CA096739 · NCI · UNIVERSITY OF AKRON · PI YOUNGS, WILEY J · 2002 to 2002
$147k
NCI NIH HHS R15 CA096739NIDDK NIH HHS R01 DK082546
6 · The paper itself

Abstract

A series of novel bis-imidazolium salts was synthesized, characterized, and evaluated in vitro against a panel of non-small cell lung cancer (NSCLC) cells. Two imidazolium cores were connected with alkyl chains of varying lengths to develop a structure activity relationship (SAR). Increasing the length of the connecting alkyl chain was shown to correlate to an increase in the anti-proliferative activity. The National Cancer Institute's NCI-60 human tumor cell line screen confirmed this trend. The compound containing a decyl linker chain, 10, was chosen for further in vivo toxicity studies with C578BL/6 mice. The compound was well tolerated by the mice and all of the animals survived and gained weight over the course of the study.

Indexed as

AnimalsAntineoplastic AgentsCell Line, TumorCell ProliferationCrystallography, X-RayDose-Response Relationship, DrugDrug Screening Assays, AntitumorHumansImidazolesMiceMice, Inbred C57BLModels, MolecularMolecular StructureSaltsStructure-Activity RelationshipAntineoplastic AgentsImidazolesSaltsBis-imidazolium saltImidazolium saltIn vivo toxicityNon-small cell lung cancerSAR

Identifiers

PMID33333447
PMCPMC7903221

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.