Evidence map›Paper›PMID 33333319›Full record

ArticleNeuroImage2021

Clarifying the role of higher-level cortices in resolving perceptual ambiguity using ultra high field fMRI.

Logan T Dowdle, Geoffrey Ghose, Kamil Ugurbil, Essa Yacoub, Luca Vizioli

Abstract read
In one paragraph

Article in NeuroImage, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Logan T DowdleCenter for Magnetic Resonance Research, University of Minnesota 2021 6th St SE, Minneapolis, MN 55455, United States; Department of Neuroscience, University of Minnesota, 321 Church St SE, Minneapolis, MN 55455. Electronic address: logan.dowdle@gmail.com.
Geoffrey GhoseCenter for Magnetic Resonance Research, University of Minnesota 2021 6th St SE, Minneapolis, MN 55455, United States; Department of Neuroscience, University of Minnesota, 321 Church St SE, Minneapolis, MN 55455.
Kamil UgurbilCenter for Magnetic Resonance Research, University of Minnesota 2021 6th St SE, Minneapolis, MN 55455, United States.
Essa YacoubCenter for Magnetic Resonance Research, University of Minnesota 2021 6th St SE, Minneapolis, MN 55455, United States.
Luca VizioliCenter for Magnetic Resonance Research, University of Minnesota 2021 6th St SE, Minneapolis, MN 55455, United States; Department of Neurosurgery, University of Minnesota, 500 SE Harvard St, Minneapolis, MN 55455. Electronic address: luca.vizioli1@gmail.com.

Funding

TRD4 - Ultrahigh Field Engineering and SafetyP41EB027061 · NIBIB · UNIVERSITY OF MINNESOTA · PI Gregory John Metzger · 2019 to 2026
$11.7M
Institutional Center Cores for Advanced NeuroimagingP30NS076408 · NINDS · UNIVERSITY OF MINNESOTA · PI UGURBIL, KAMIL · 2012 to 2020
$4.2M
Linking neuronal, metabolic, and hemodynamic responses across scalesRF1MH117015 · NIMH · UNIVERSITY OF MINNESOTA · PI GHOSE, GEOFFREY M · 2018 to 2018
$3.6M
The Neuronal Underpinnings of Non-invasive Laminar fMRIRF1MH116978 · NIMH · UNIVERSITY OF MINNESOTA · PI DEVINSKY, ORRIN, YACOUB, ESSA · 2018 to 2018
$2.9M
NIBIB NIH HHS P41 EB027061NIMH NIH HHS RF1 MH116978NIMH NIH HHS RF1 MH117015NINDS NIH HHS P30 NS076408
6 · The paper itself

Abstract

The brain is organized into distinct, flexible networks. Within these networks, cognitive variables such as attention can modulate sensory representations in accordance with moment-to-moment behavioral requirements. These modulations can be studied by varying task demands; however, the tasks employed are often incongruent with the postulated functions of a sensory system, limiting the characterization of the system in relation to natural behaviors. Here we combine domain-specific task manipulations and ultra-high field fMRI to study the nature of top-down modulations. We exploited faces, a visual category underpinned by a complex cortical network, and instructed participants to perform either a stimulus-relevant/domain-specific or a stimulus-irrelevant task in the scanner. We found that 1. perceptual ambiguity (i.e. difficulty of achieving a stable percept) is encoded in top-down modulations from higher-level cortices; 2. the right inferior-temporal lobe is active under challenging conditions and uniquely encodes trial-by-trial variability in face perception.

Indexed as

AdolescentAdultAttentionBrain MappingCerebral CortexFemaleHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMalePhotic StimulationVisual PerceptionYoung AdultCognitive NeuroscienceCortical NetworkfMRIPerceptionTask modulationsTop-downUltra High FieldVision

Identifiers

PMID33333319
PMCPMC10614695

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.