Evidence map›Paper›PMID 33333089›Full record

ArticleJournal of neuroscience methods2021

Probing neural tissues at small scales: Recent progress of oscillating gradient spin echo (OGSE) neuroimaging in humans.

Junzhong Xu

Open access · greenAbstract read
In one paragraph

Article in Journal of neuroscience methods, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
2.3field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 41 citations in OpenAlex.

  1. Article
  2. Article
  3. Microstructure mapping with time-dependent diffusion MRI differentiates primary central nervous system lymphoma from glioblastoma.Cancer imaging : the official publication of the International Cancer Imaging Society · 2026
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Engineering clinical translation of OGSE diffusion MRI.Magnetic resonance in medicine · 2025
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Diffusion time dependency of extracellular diffusion.Magnetic resonance in medicine · 2023
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Junzhong XuVanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, 37232, USA; Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, 37232, USA; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, 37232, USA; Department of Physics and Astronomy, Vanderbilt University, Nashville, TN, 37232, USA. Electronic address: junzhong.xu@vanderbilt.edu.
Vanderbilt University · US

Funding

MRI Diffusion in Tumors Using Oscillating GradientsR01CA109106 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI XU, JUNZHONG · 2006 to 2022
$4.0M
Disposable Perfusion Phantom for Accurate DCE-MRI Measurement of Pancreatic Cancer Therapy ResponseUH3CA232820 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI EL-RAYES, BASSEL · 2021 to 2023
$1.4M
Disposable Perfusion Phantom for Accurate DCE-MRI Measurement of Pancreatic Cancer Therapy ResponseUG3CA232820 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KIM, HARRISON · 2019 to 2020
$763k
NCI NIH HHS R01 CA109106NCI NIH HHS UG3 CA232820NCI NIH HHS UH3 CA232820
6 · The paper itself

Abstract

The detection sensitivity of diffusion MRI (dMRI) is dependent on diffusion times. A shorter diffusion time can increase the sensitivity to smaller length scales. However, the conventional dMRI uses the pulse gradient spin echo (PGSE) sequence that probes relatively long diffusion times only. To overcome this, the oscillating gradient spin echo (OGSE) sequence has been developed to probe much shorter diffusion times with hardware limitations on preclinical and clinical MRI systems. The OGSE sequence has been previously used on preclinical animal MRI systems. Recently, several studies have translated the OGSE sequence to humans on clinical MRI systems and achieved new information that is invisible using conventional PGSE sequence. This paper provides an overview of the recent progress of the OGSE neuroimaging in humans, including the technical improvements in the translation of the OGSE sequence to human imaging and various applications in different neurological disorders and stroke. Some possible future directions of the OGSE sequence are also discussed.

Indexed as

Diffusion Magnetic Resonance ImagingNeuroimagingAnimalsDiffusionHumansMagnetic Resonance ImagingDiffusionDiffusion dispersionDiffusion timeMicrostructureMRIOscillating gradientSize

Identifiers

PMID33333089
PMCPMC10124150
OpenAlexW3111506614

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.