Evidence map›Paper›PMID 33333066›Full record

ArticleDevelopmental biology2021

Interdependent regulation of stereotyped and stochastic photoreceptor fates in the fly eye.

Adam C Miller, Elizabeth A Urban, Eric L Lyons, Tory G Herman, Robert J Johnston

Open access · hybridAbstract read
In one paragraph

Article in Developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Deep conservation complemented by novelty and innovation in the insect eye ground plan.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Article
  4. Transcriptional priming and chromatin regulation during stochastic cell fate specification.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024
    Review
  5. Review
  6. Insect opsins and evo-devo: what have we learned in 25 years?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Adam C MillerInstitute of Molecular Biology, University of Oregon, Eugene, OR, 97403, USA.
Elizabeth A UrbanDepartment of Biology, Johns Hopkins University, 3400 N Charles Street, Baltimore, MD, 21218-2685, USA.
Eric L LyonsInstitute of Molecular Biology, University of Oregon, Eugene, OR, 97403, USA.
Tory G HermanInstitute of Molecular Biology, University of Oregon, Eugene, OR, 97403, USA. Electronic address: herman@uoregon.edu.
Robert J JohnstonDepartment of Biology, Johns Hopkins University, 3400 N Charles Street, Baltimore, MD, 21218-2685, USA. Electronic address: robertjohnston@jhu.edu.
Johns Hopkins University · USUniversity of Oregon · USOregon Research Institute · US

Funding

Graduate Training in Genetics Administrative Supplement - Career Curriculum DevelopmentT32GM007413 · NIGMS · UNIVERSITY OF OREGON · PI GUILLEMIN, KAREN J · 1985 to 2022
$7.8M
DEVELOPMENTAL BIOLOGY TRAINING PROGRAMT32HD007348 · NICHD · UNIVERSITY OF OREGON · PI Chris Q Doe, KRYN STANKUNAS · 1989 to 2026
$6.8M
Mechanisms controlling stochastic gene expression during eye developmentR01EY025598 · NEI · JOHNS HOPKINS UNIVERSITY · PI Robert John Johnston · 2015 to 2026
$4.9M
NEI NIH HHS R01 EY025598NICHD NIH HHS T32 HD007348NIGMS NIH HHS T32 GM007413
6 · The paper itself

Abstract

Diversification of neuronal subtypes often requires stochastic gene regulatory mechanisms. How stochastically expressed transcription factors interact with other regulators in gene networks to specify cell fates is poorly understood. The random mosaic of color-detecting R7 photoreceptor subtypes in Drosophila is controlled by the stochastic on/off expression of the transcription factor Spineless (Ss). In Ss

Indexed as

Gene Expression Regulation, DevelopmentalAnimalsDrosophila melanogasterDrosophila ProteinsPhotoreceptor Cells, InvertebrateReceptors, Aryl HydrocarbonRhodopsinDrosophila ProteinsReceptors, Aryl HydrocarbonRhodopsinss protein, DrosophilaFeedbackFeedforward loopPhotoreceptorRuntSpinelessStochastic

Identifiers

PMID33333066
PMCPMC7856283
OpenAlexW3113262488

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.