Evidence map›Paper›PMID 33333001›Full record

ArticleNeuron2021

Activity labeling in vivo using CaMPARI2 reveals intrinsic and synaptic differences between neurons with high and low firing rate set points.

Nicholas F Trojanowski, Juliet Bottorff, Gina G Turrigiano

Open access · bronzeAbstract read
In one paragraph

Article in Neuron, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
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  3. Review
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  5. Spatial Mapping of Activity Changes across Sensory Areas Following Visual Deprivation in Adults.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  6. Basal forebrain cholinergic activity is necessary for upward firing rate homeostasis in the rodent visual cortex.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  7. Article
  8. Review
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  10. Creation of Neuronal Ensembles and Cell-Specific Homeostatic Plasticity through Chronic Sparse Optogenetic Stimulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  11. Review
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  14. Paradoxical self-sustained dynamics emerge from orchestrated excitatory and inhibitory homeostatic plasticity rules.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  15. Article
  16. Developmental Regulation of Homeostatic Plasticity in Mouse Primary Visual Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Nicholas F TrojanowskiDepartment of Biology, Brandeis University, Waltham, MA 02453, USA.
Juliet BottorffDepartment of Biology, Brandeis University, Waltham, MA 02453, USA.
Gina G TurrigianoDepartment of Biology, Brandeis University, Waltham, MA 02453, USA. Electronic address: turrigiano@brandeis.edu.
Brandeis University · US

Funding

Quantitative Neuroscience: Tools for Bridging Levels of AnalysisT32NS007292 · NINDS · BRANDEIS UNIVERSITY · PI GINA G TURRIGIANO · 1986 to 2026
$12.7M
Mechanisms and Function of Firing Rate Homeostasis in Cortical CircuitsR35NS111562 · NINDS · BRANDEIS UNIVERSITY · PI GINA G TURRIGIANO · 2019 to 2026
$7.3M
The role of CaMKIV signaling in determining firing rate set pointsF32NS101832 · NINDS · BRANDEIS UNIVERSITY · PI TROJANOWSKI, NICHOLAS · 2017 to 2018
$116k
Behavioral State Gating of Neuroplasticity: The Role of State-Specific Neuromodulators in Firing Rate HomeostasisF31EY031602 · NEI · BRANDEIS UNIVERSITY · PI BOTTORFF, JULIET · 2020 to 2022
$94k
NEI NIH HHS F31 EY031602NINDS NIH HHS F32 NS101832NINDS NIH HHS R35 NS111562NINDS NIH HHS T32 NS007292
6 · The paper itself

Abstract

Neocortical pyramidal neurons regulate firing around a stable mean firing rate (FR) that can differ by orders of magnitude between neurons, but the factors that determine where individual neurons sit within this broad FR distribution are not understood. To access low- and high-FR neurons for ex vivo analysis, we used Ca

Indexed as

AnimalsCalciumExcitatory Postsynaptic PotentialsFemaleInhibitory Postsynaptic PotentialsMaleMiceMice, Inbred C57BLMice, TransgenicNeuronsPyramidal CellsSynaptic TransmissionUltraviolet RaysCalciumCaMPARI2cortical connectivityE/I ratioexcitatory synaptic strengthfiring rate homeostasisfiring rate set pointintrinsic excitability

Identifiers

PMID33333001
PMCPMC7897300
OpenAlexW3110842501

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.