ArticleAmerican journal of respiratory and critical care medicine2021
Inflammatory Endotype-associated Airway Microbiome in Chronic Obstructive Pulmonary Disease Clinical Stability and Exacerbations: A Multicohort Longitudinal Analysis.
Open access · hybridAbstract readMulticenter Study
In one paragraph
Article in American journal of respiratory and critical care medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 151 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
151citing papers in PubMed, 1 pooled it
12.0field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
151 citing papers in PubMed, 1 synthesis or guideline pooled it, 283 citations in OpenAlex.
- Bacteria of the lung microbiome and health biomarkers in chronic airway disease: a systematic review and meta-analysis.NPJ biofilms and microbiomes · 2026Pooled it
- Trial
- Can Treatable Traits Be the Approach to Addressing the Complexity and Heterogeneity of COPD?International journal of chronic obstructive pulmonary disease · 2023Trial
- Benefits of Budesonide/Glycopyrronium/Formoterol Fumarate Dihydrate on COPD Exacerbations, Lung Function, Symptoms, and Quality of Life Across Blood Eosinophil Ranges: A Post-Hoc Analysis of Data from ETHOS.International journal of chronic obstructive pulmonary disease · 2022Trial
- Assessment of bacterial exposure on phagocytic capability and surface marker expression of sputum macrophages and neutrophils in COPD patients.Clinical and experimental immunology · 2021Trial
- The role of the respiratory microbiome in acute and chronic respiratory diseases.Nature reviews. Microbiology · 2026Review
- Review
- Ozone Exposure Induces Pulmonary Microbiota Dysbiosis and Associated Inflammatory Responses in Mice.Toxics · 2026Article
- The associations of human genetic variations with airway microbiome, environmental exposures, and respiratory health.mSystems · 2026Article
- Airway microbiota in young people across four continents differ by country, asthma status and inflammatory phenotype.Thorax · 2026Article
- Microbiota-Immune Crosstalk in Pneumonia and Acute Lung Injury: Mechanisms, Evidence, and Therapeutic Opportunities.Microorganisms · 2026Review
- Dynamic balance of the lung microbiome in health and respiratory diseases.Chinese medical journal · 2026Review
- The Role of Polyphenols in Respiratory and Gut Health: From the Perspective of Gut-Lung Axis.Phytotherapy research : PTR · 2026Review
- The Gut-Lung Microbiome Axis in Alveolar Stem Cell Regeneration and Lung Repair.Microorganisms · 2026Review
- Multi-site microbiomes' response to chronic obstructive pulmonary disease.Microbiology spectrum · 2026Article
- Metatranscriptomic analysis of upper and lower respiratory tract microbiomes in patients with tuberculosis and community-acquired pneumonia.BMC infectious diseases · 2026Article
- Bronchial and Systemic Relationships ofInternational journal of molecular sciences · 2026Article
- Bacterial taxa associated with lung cancer cases in Southeast Asians: a pilot case-control study.Cellular oncology (Dordrecht, Netherlands) · 2026Article
- Aconiti Lateralis Radix Praeparata active ingredients of Heishunpian potential on LPS-induced Nrf-2/NQO1/HO-1 and Smad3/Akt/p38 signalling pathways in chronic obstructive pulmonary disease: a network pharmacology study.Journal of molecular histology · 2026Article
- Longitudinal change of lung microbiome in chronic obstructive pulmonary disease: a prospective cohort study.Respiratory research · 2026Article
91 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
16 authors at 7 institutions in 4 countries.
Zhang WangInstitute of Ecological Sciences, School of Life Sciences, South China Normal University, Guangzhou, China.
Nicholas LocantoreMedical Innovation, Value Evidence and Outcomes, and.
Koirobi HaldarHuman Genetics, Research and Development, GlaxoSmithKline, Collegeville, Pennsylvania.
Mohammadali Yavari RamshehHuman Genetics, Research and Development, GlaxoSmithKline, Collegeville, Pennsylvania.
Augusta S BeechDepartment of Respiratory Sciences, Institute for Lung Health, Leicester National Institute for Health Research Biomedical Research Centre, University of Leicester, Leicester, United Kingdom.
Wei MaDivision of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom.
James R BrownInstitute of Statistics and Big Data, Renmin University of China, Beijing, China.
Ruth Tal-SingerChronic Obstructive Pulmonary Disease Foundation, Research Department, Washington, District of Columbia.
Michael R BarerHuman Genetics, Research and Development, GlaxoSmithKline, Collegeville, Pennsylvania.
Mona BafadhelRespiratory Medicine Unit, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.ORCID 0000-0002-9993-2478
Gavin C DonaldsonNational Heart and Lung Institute, Imperial College London, London, United Kingdom; and.
Jadwiga A WedzichaNational Heart and Lung Institute, Imperial College London, London, United Kingdom; and.
Dave SinghDepartment of Respiratory Sciences, Institute for Lung Health, Leicester National Institute for Health Research Biomedical Research Centre, University of Leicester, Leicester, United Kingdom.
Tom M A WilkinsonNational Institute for Health Research Southampton Respiratory Biomedical Research Unit, University Hospital Southampton National Health Service Foundation Trust, Southampton, United Kingdom.
Bruce E MillerMedical Innovation, Value Evidence and Outcomes, and.
Christopher E BrightlingHuman Genetics, Research and Development, GlaxoSmithKline, Collegeville, Pennsylvania.
University of Leicester · GBGlaxoSmithKline (United States) · USImperial College London · GBManchester Academic Health Science Centre · GBNational Health Service · GBSouth China Normal University · CNUniversity of Oxford · GB
Funding
Medical Research Council G0601369Medical Research Council G0800570Medical Research Council G1001365
Abstract
PubMed holds no abstract for this paper.
Indexed as
MicrobiotaAgedAged, 80 and overBiomarkersCohort StudiesEosinophiliaFemaleHumansMaleMiddle AgedNeutrophilsPulmonary Disease, Chronic ObstructiveSputumUnited KingdomBiomarkersairway microbiomechronic obstructive pulmonary diseasecytokinesinflammatory endotypesunbiased clusters
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.