Trial reportThe New England journal of medicine2021
REGN-COV2, a Neutralizing Antibody Cocktail, in Outpatients with Covid-19.
4 registry-linked trialsAbstract readClinical Trial, Phase IClinical Trial, Phase IIMulticenter Study
In one paragraph
Trial report in The New England journal of medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 1,032 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
1,032citing papers in PubMed, 2 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Master Protocol Assessing the Safety, Tolerability, and Efficacy of Anti-Spike (S) SARS-CoV-2 Monoclonal Antibodies for the Treatment of Ambulatory Patients With COVID-19
Clinical Study to Evaluate the Possible Efficacy and Safety of Antibodies Combination (Casirivimab and Imdevimab) Versus Standard Antiviral Therapy (Remdesivir and Favipravir) as Antiviral Agent Against Corona Virus 2 Infection in Hospitalized COVID-19 Patients
NCT05648110 phase2 / phase3completednot on this mapstarted 2022, after this paper: background citation
A Phase I/III Randomized, Double-blind Study to Evaluate the Safety, Efficacy and Neutralizing Activity of AZD5156/AZD3152 for Pre-exposure Prophylaxis of COVID-19 in Participants With Conditions Causing Immune Impairment. Sub-study: Phase II Open Label Sub-study to Evaluate the Safety, PK, and Neutralizing Activity of AZD3152 for Pre-exposure Prophylaxis of COVID-19
NCT06917001 phase2not yet recruitingnot on this mapstarted 2026, after this paper: background citation
A Randomized, Double-blind, Placebo-controled, Phase 2a Trial Evaluating the Safety and Initial Efficacy of Resomelagon in Patients With Dengue Infection
Who cites it
1,032 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- Coronavirus Disease 2019 Convalescent Plasma Outpatient Therapy to Prevent Outpatient Hospitalization: A Meta-Analysis of Individual Participant Data From 5 Randomized Trials.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Pooled it
- Pharmacokinetics, Immunogenicity, and Safety of a Modified YTE Antibody in Healthy Adults.Clinical pharmacology in drug development · 2026Trial
- Impact of COVID-19 Monoclonal Antibody Therapy on Subsequent Vaccine-Elicited SARS-CoV-2 Immune Responses.The Journal of infectious diseases · 2026Trial
- Effect of inhaled interferon-β1a on SARS-CoV-2 diversity and evolution.Microbiology spectrum · 2026Trial
- Molnupiravir or nirmatrelvir-ritonavir plus usual care versus usual care alone in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.The Lancet. Infectious diseases · 2025Trial
- Long-term outcomes of passive immunotherapy for COVID-19: a pooled analysis of a large multinational platform randomized clinical trial.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2025Trial
- Safety and Pharmacokinetics of Casirivimab and Imdevimab (CAS + IMD) in Pediatric Outpatients With COVID-19.Journal of the Pediatric Infectious Diseases Society · 2024Trial
- SARS-CoV-2 Monoclonal Antibody Treatment Followed by Vaccination Shifts Human Memory B-Cell Epitope Recognition, Suggesting Antibody Feedback.The Journal of infectious diseases · 2024Trial
- Trial
- Characterization of Treatment Resistance and Viral Kinetics in the Setting of Single-Active Versus Dual-Active Monoclonal Antibodies Against Severe Acute Respiratory Syndrome Coronavirus 2.The Journal of infectious diseases · 2024Trial
- Clinical antiviral efficacy of favipiravir in early COVID-19 (PLATCOV): an open-label, randomised, controlled, adaptive platform trial.BMC infectious diseases · 2024Trial
- Association between SARS-CoV-2 viral kinetics and clinical score evolution in hospitalized patients.CPT: pharmacometrics & systems pharmacology · 2023Trial
- Comparing the efficacy of regen-cov, remdesivir, and favipiravir in reducing invasive mechanical ventilation need in hospitalized COVID-19 patients.World journal of clinical cases · 2023Trial
- Statistical Challenges When Analyzing SARS-CoV-2 RNA Measurements Below the Assay Limit of Quantification in COVID-19 Clinical Trials.The Journal of infectious diseases · 2023Trial
- Casirivimab + imdevimab accelerates symptom resolution linked to improved COVID-19 outcomes across susceptible antibody and risk profiles.Scientific reports · 2023Trial
- Prognostic value of severe acute respiratory syndrome coronavirus-2 viral load and antibodies in patients hospitalized with COVID-19.Clinical and translational science · 2023Trial
- Safety, Tolerability and Pharmacokinetics of Half-Life Extended Severe Acute Respiratory Syndrome Coronavirus 2 Neutralizing Monoclonal Antibodies AZD7442 (Tixagevimab-Cilgavimab) in Healthy Adults.The Journal of infectious diseases · 2023Trial
- Safety and Efficacy of Combined Tixagevimab and Cilgavimab Administered Intramuscularly or Intravenously in Nonhospitalized Patients With COVID-19: 2 Randomized Clinical Trials.JAMA network open · 2023Trial
- Synthesis of 1,3,5-Triazine-Indole Conjugates as Broad-Spectrum Coronavirus Entry Inhibitors.ChemMedChem · 2026Article
972 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
34 authors.
David M WeinreichFrom Regeneron Pharmaceuticals, Tarrytown, NY (D.M.W., S.S., T.N., S.A., H.G., R.B., B.J.M., Y. Soo, D.R., J.I., C. Perry, C. Pan, R.H., A.M., J.D.D., K.C.T., A.T.H., J.D.H., A.B., C.A.K., Y.K., A.C., W.K., B.K., T.D., N.S., L.L., N.B., G.H., G.D.Y.); Arizona Liver Health, Tucson (A.K.), and Arizona Liver Health, Chandler (Y. Sachdeva); and AGA Clinical Trials, Hialeah, FL (X.G.).
Sumathi SivapalasingamFrom Regeneron Pharmaceuticals, Tarrytown, NY (D.M.W., S.S., T.N., S.A., H.G., R.B., B.J.M., Y. Soo, D.R., J.I., C. Perry, C. Pan, R.H., A.M., J.D.D., K.C.T., A.T.H., J.D.H., A.B., C.A.K., Y.K., A.C., W.K., B.K., T.D., N.S., L.L., N.B., G.H., G.D.Y.); Arizona Liver Health, Tucson (A.K.), and Arizona Liver Health, Chandler (Y. Sachdeva); and AGA Clinical Trials, Hialeah, FL (X.G.).
Thomas NortonFrom Regeneron Pharmaceuticals, Tarrytown, NY (D.M.W., S.S., T.N., S.A., H.G., R.B., B.J.M., Y. Soo, D.R., J.I., C. Perry, C. Pan, R.H., A.M., J.D.D., K.C.T., A.T.H., J.D.H., A.B., C.A.K., Y.K., A.C., W.K., B.K., T.D., N.S., L.L., N.B., G.H., G.D.Y.); Arizona Liver Health, Tucson (A.K.), and Arizona Liver Health, Chandler (Y. Sachdeva); and AGA Clinical Trials, Hialeah, FL (X.G.).
Shazia AliFrom Regeneron Pharmaceuticals, Tarrytown, NY (D.M.W., S.S., T.N., S.A., H.G., R.B., B.J.M., Y. Soo, D.R., J.I., C. Perry, C. Pan, R.H., A.M., J.D.D., K.C.T., A.T.H., J.D.H., A.B., C.A.K., Y.K., A.C., W.K., B.K., T.D., N.S., L.L., N.B., G.H., G.D.Y.); Arizona Liver Health, Tucson (A.K.), and Arizona Liver Health, Chandler (Y. Sachdeva); and AGA Clinical Trials, Hialeah, FL (X.G.).
Haitao GaoFrom Regeneron Pharmaceuticals, Tarrytown, NY (D.M.W., S.S., T.N., S.A., H.G., R.B., B.J.M., Y. Soo, D.R., J.I., C. Perry, C. Pan, R.H., A.M., J.D.D., K.C.T., A.T.H., J.D.H., A.B., C.A.K., Y.K., A.C., W.K., B.K., T.D., N.S., L.L., N.B., G.H., G.D.Y.); Arizona Liver Health, Tucson (A.K.), and Arizona Liver Health, Chandler (Y. Sachdeva); and AGA Clinical Trials, Hialeah, FL (X.G.).
Rafia BhoreFrom Regeneron Pharmaceuticals, Tarrytown, NY (D.M.W., S.S., T.N., S.A., H.G., R.B., B.J.M., Y. Soo, D.R., J.I., C. Perry, C. Pan, R.H., A.M., J.D.D., K.C.T., A.T.H., J.D.H., A.B., C.A.K., Y.K., A.C., W.K., B.K., T.D., N.S., L.L., N.B., G.H., G.D.Y.); Arizona Liver Health, Tucson (A.K.), and Arizona Liver Health, Chandler (Y. Sachdeva); and AGA Clinical Trials, Hialeah, FL (X.G.).
Bret J MusserFrom Regeneron Pharmaceuticals, Tarrytown, NY (D.M.W., S.S., T.N., S.A., H.G., R.B., B.J.M., Y. Soo, D.R., J.I., C. Perry, C. Pan, R.H., A.M., J.D.D., K.C.T., A.T.H., J.D.H., A.B., C.A.K., Y.K., A.C., W.K., B.K., T.D., N.S., L.L., N.B., G.H., G.D.Y.); Arizona Liver Health, Tucson (A.K.), and Arizona Liver Health, Chandler (Y. Sachdeva); and AGA Clinical Trials, Hialeah, FL (X.G.).
Yuhwen SooFrom Regeneron Pharmaceuticals, Tarrytown, NY (D.M.W., S.S., T.N., S.A., H.G., R.B., B.J.M., Y. Soo, D.R., J.I., C. Perry, C. Pan, R.H., A.M., J.D.D., K.C.T., A.T.H., J.D.H., A.B., C.A.K., Y.K., A.C., W.K., B.K., T.D., N.S., L.L., N.B., G.H., G.D.Y.); Arizona Liver Health, Tucson (A.K.), and Arizona Liver Health, Chandler (Y. Sachdeva); and AGA Clinical Trials, Hialeah, FL (X.G.).
Diana RofailFrom Regeneron Pharmaceuticals, Tarrytown, NY (D.M.W., S.S., T.N., S.A., H.G., R.B., B.J.M., Y. Soo, D.R., J.I., C. Perry, C. Pan, R.H., A.M., J.D.D., K.C.T., A.T.H., J.D.H., A.B., C.A.K., Y.K., A.C., W.K., B.K., T.D., N.S., L.L., N.B., G.H., G.D.Y.); Arizona Liver Health, Tucson (A.K.), and Arizona Liver Health, Chandler (Y. Sachdeva); and AGA Clinical Trials, Hialeah, FL (X.G.).
Joseph ImFrom Regeneron Pharmaceuticals, Tarrytown, NY (D.M.W., S.S., T.N., S.A., H.G., R.B., B.J.M., Y. Soo, D.R., J.I., C. Perry, C. Pan, R.H., A.M., J.D.D., K.C.T., A.T.H., J.D.H., A.B., C.A.K., Y.K., A.C., W.K., B.K., T.D., N.S., L.L., N.B., G.H., G.D.Y.); Arizona Liver Health, Tucson (A.K.), and Arizona Liver Health, Chandler (Y. Sachdeva); and AGA Clinical Trials, Hialeah, FL (X.G.).
Christina PerryFrom Regeneron Pharmaceuticals, Tarrytown, NY (D.M.W., S.S., T.N., S.A., H.G., R.B., B.J.M., Y. Soo, D.R., J.I., C. Perry, C. Pan, R.H., A.M., J.D.D., K.C.T., A.T.H., J.D.H., A.B., C.A.K., Y.K., A.C., W.K., B.K., T.D., N.S., L.L., N.B., G.H., G.D.Y.); Arizona Liver Health, Tucson (A.K.), and Arizona Liver Health, Chandler (Y. Sachdeva); and AGA Clinical Trials, Hialeah, FL (X.G.).
Cynthia PanFrom Regeneron Pharmaceuticals, Tarrytown, NY (D.M.W., S.S., T.N., S.A., H.G., R.B., B.J.M., Y. Soo, D.R., J.I., C. Perry, C. Pan, R.H., A.M., J.D.D., K.C.T., A.T.H., J.D.H., A.B., C.A.K., Y.K., A.C., W.K., B.K., T.D., N.S., L.L., N.B., G.H., G.D.Y.); Arizona Liver Health, Tucson (A.K.), and Arizona Liver Health, Chandler (Y. Sachdeva); and AGA Clinical Trials, Hialeah, FL (X.G.).
Romana HosainFrom Regeneron Pharmaceuticals, Tarrytown, NY (D.M.W., S.S., T.N., S.A., H.G., R.B., B.J.M., Y. Soo, D.R., J.I., C. Perry, C. Pan, R.H., A.M., J.D.D., K.C.T., A.T.H., J.D.H., A.B., C.A.K., Y.K., A.C., W.K., B.K., T.D., N.S., L.L., N.B., G.H., G.D.Y.); Arizona Liver Health, Tucson (A.K.), and Arizona Liver Health, Chandler (Y. Sachdeva); and AGA Clinical Trials, Hialeah, FL (X.G.).
Adnan MahmoodFrom Regeneron Pharmaceuticals, Tarrytown, NY (D.M.W., S.S., T.N., S.A., H.G., R.B., B.J.M., Y. Soo, D.R., J.I., C. Perry, C. Pan, R.H., A.M., J.D.D., K.C.T., A.T.H., J.D.H., A.B., C.A.K., Y.K., A.C., W.K., B.K., T.D., N.S., L.L., N.B., G.H., G.D.Y.); Arizona Liver Health, Tucson (A.K.), and Arizona Liver Health, Chandler (Y. Sachdeva); and AGA Clinical Trials, Hialeah, FL (X.G.).
John D DavisFrom Regeneron Pharmaceuticals, Tarrytown, NY (D.M.W., S.S., T.N., S.A., H.G., R.B., B.J.M., Y. Soo, D.R., J.I., C. Perry, C. Pan, R.H., A.M., J.D.D., K.C.T., A.T.H., J.D.H., A.B., C.A.K., Y.K., A.C., W.K., B.K., T.D., N.S., L.L., N.B., G.H., G.D.Y.); Arizona Liver Health, Tucson (A.K.), and Arizona Liver Health, Chandler (Y. Sachdeva); and AGA Clinical Trials, Hialeah, FL (X.G.).ORCID 0000-0001-6282-1670
Kenneth C TurnerFrom Regeneron Pharmaceuticals, Tarrytown, NY (D.M.W., S.S., T.N., S.A., H.G., R.B., B.J.M., Y. Soo, D.R., J.I., C. Perry, C. Pan, R.H., A.M., J.D.D., K.C.T., A.T.H., J.D.H., A.B., C.A.K., Y.K., A.C., W.K., B.K., T.D., N.S., L.L., N.B., G.H., G.D.Y.); Arizona Liver Health, Tucson (A.K.), and Arizona Liver Health, Chandler (Y. Sachdeva); and AGA Clinical Trials, Hialeah, FL (X.G.).
Andrea T HooperFrom Regeneron Pharmaceuticals, Tarrytown, NY (D.M.W., S.S., T.N., S.A., H.G., R.B., B.J.M., Y. Soo, D.R., J.I., C. Perry, C. Pan, R.H., A.M., J.D.D., K.C.T., A.T.H., J.D.H., A.B., C.A.K., Y.K., A.C., W.K., B.K., T.D., N.S., L.L., N.B., G.H., G.D.Y.); Arizona Liver Health, Tucson (A.K.), and Arizona Liver Health, Chandler (Y. Sachdeva); and AGA Clinical Trials, Hialeah, FL (X.G.).
Jennifer D HamiltonFrom Regeneron Pharmaceuticals, Tarrytown, NY (D.M.W., S.S., T.N., S.A., H.G., R.B., B.J.M., Y. Soo, D.R., J.I., C. Perry, C. Pan, R.H., A.M., J.D.D., K.C.T., A.T.H., J.D.H., A.B., C.A.K., Y.K., A.C., W.K., B.K., T.D., N.S., L.L., N.B., G.H., G.D.Y.); Arizona Liver Health, Tucson (A.K.), and Arizona Liver Health, Chandler (Y. Sachdeva); and AGA Clinical Trials, Hialeah, FL (X.G.).
Alina BaumFrom Regeneron Pharmaceuticals, Tarrytown, NY (D.M.W., S.S., T.N., S.A., H.G., R.B., B.J.M., Y. Soo, D.R., J.I., C. Perry, C. Pan, R.H., A.M., J.D.D., K.C.T., A.T.H., J.D.H., A.B., C.A.K., Y.K., A.C., W.K., B.K., T.D., N.S., L.L., N.B., G.H., G.D.Y.); Arizona Liver Health, Tucson (A.K.), and Arizona Liver Health, Chandler (Y. Sachdeva); and AGA Clinical Trials, Hialeah, FL (X.G.).
Christos A KyratsousFrom Regeneron Pharmaceuticals, Tarrytown, NY (D.M.W., S.S., T.N., S.A., H.G., R.B., B.J.M., Y. Soo, D.R., J.I., C. Perry, C. Pan, R.H., A.M., J.D.D., K.C.T., A.T.H., J.D.H., A.B., C.A.K., Y.K., A.C., W.K., B.K., T.D., N.S., L.L., N.B., G.H., G.D.Y.); Arizona Liver Health, Tucson (A.K.), and Arizona Liver Health, Chandler (Y. Sachdeva); and AGA Clinical Trials, Hialeah, FL (X.G.).
Yunji KimFrom Regeneron Pharmaceuticals, Tarrytown, NY (D.M.W., S.S., T.N., S.A., H.G., R.B., B.J.M., Y. Soo, D.R., J.I., C. Perry, C. Pan, R.H., A.M., J.D.D., K.C.T., A.T.H., J.D.H., A.B., C.A.K., Y.K., A.C., W.K., B.K., T.D., N.S., L.L., N.B., G.H., G.D.Y.); Arizona Liver Health, Tucson (A.K.), and Arizona Liver Health, Chandler (Y. Sachdeva); and AGA Clinical Trials, Hialeah, FL (X.G.).
Amanda CookFrom Regeneron Pharmaceuticals, Tarrytown, NY (D.M.W., S.S., T.N., S.A., H.G., R.B., B.J.M., Y. Soo, D.R., J.I., C. Perry, C. Pan, R.H., A.M., J.D.D., K.C.T., A.T.H., J.D.H., A.B., C.A.K., Y.K., A.C., W.K., B.K., T.D., N.S., L.L., N.B., G.H., G.D.Y.); Arizona Liver Health, Tucson (A.K.), and Arizona Liver Health, Chandler (Y. Sachdeva); and AGA Clinical Trials, Hialeah, FL (X.G.).
Wendy KampmanFrom Regeneron Pharmaceuticals, Tarrytown, NY (D.M.W., S.S., T.N., S.A., H.G., R.B., B.J.M., Y. Soo, D.R., J.I., C. Perry, C. Pan, R.H., A.M., J.D.D., K.C.T., A.T.H., J.D.H., A.B., C.A.K., Y.K., A.C., W.K., B.K., T.D., N.S., L.L., N.B., G.H., G.D.Y.); Arizona Liver Health, Tucson (A.K.), and Arizona Liver Health, Chandler (Y. Sachdeva); and AGA Clinical Trials, Hialeah, FL (X.G.).
Anita KohliFrom Regeneron Pharmaceuticals, Tarrytown, NY (D.M.W., S.S., T.N., S.A., H.G., R.B., B.J.M., Y. Soo, D.R., J.I., C. Perry, C. Pan, R.H., A.M., J.D.D., K.C.T., A.T.H., J.D.H., A.B., C.A.K., Y.K., A.C., W.K., B.K., T.D., N.S., L.L., N.B., G.H., G.D.Y.); Arizona Liver Health, Tucson (A.K.), and Arizona Liver Health, Chandler (Y. Sachdeva); and AGA Clinical Trials, Hialeah, FL (X.G.).
Yessica SachdevaFrom Regeneron Pharmaceuticals, Tarrytown, NY (D.M.W., S.S., T.N., S.A., H.G., R.B., B.J.M., Y. Soo, D.R., J.I., C. Perry, C. Pan, R.H., A.M., J.D.D., K.C.T., A.T.H., J.D.H., A.B., C.A.K., Y.K., A.C., W.K., B.K., T.D., N.S., L.L., N.B., G.H., G.D.Y.); Arizona Liver Health, Tucson (A.K.), and Arizona Liver Health, Chandler (Y. Sachdeva); and AGA Clinical Trials, Hialeah, FL (X.G.).
Ximena GraberFrom Regeneron Pharmaceuticals, Tarrytown, NY (D.M.W., S.S., T.N., S.A., H.G., R.B., B.J.M., Y. Soo, D.R., J.I., C. Perry, C. Pan, R.H., A.M., J.D.D., K.C.T., A.T.H., J.D.H., A.B., C.A.K., Y.K., A.C., W.K., B.K., T.D., N.S., L.L., N.B., G.H., G.D.Y.); Arizona Liver Health, Tucson (A.K.), and Arizona Liver Health, Chandler (Y. Sachdeva); and AGA Clinical Trials, Hialeah, FL (X.G.).
Bari KowalFrom Regeneron Pharmaceuticals, Tarrytown, NY (D.M.W., S.S., T.N., S.A., H.G., R.B., B.J.M., Y. Soo, D.R., J.I., C. Perry, C. Pan, R.H., A.M., J.D.D., K.C.T., A.T.H., J.D.H., A.B., C.A.K., Y.K., A.C., W.K., B.K., T.D., N.S., L.L., N.B., G.H., G.D.Y.); Arizona Liver Health, Tucson (A.K.), and Arizona Liver Health, Chandler (Y. Sachdeva); and AGA Clinical Trials, Hialeah, FL (X.G.).
Thomas DiCioccioFrom Regeneron Pharmaceuticals, Tarrytown, NY (D.M.W., S.S., T.N., S.A., H.G., R.B., B.J.M., Y. Soo, D.R., J.I., C. Perry, C. Pan, R.H., A.M., J.D.D., K.C.T., A.T.H., J.D.H., A.B., C.A.K., Y.K., A.C., W.K., B.K., T.D., N.S., L.L., N.B., G.H., G.D.Y.); Arizona Liver Health, Tucson (A.K.), and Arizona Liver Health, Chandler (Y. Sachdeva); and AGA Clinical Trials, Hialeah, FL (X.G.).
Neil StahlFrom Regeneron Pharmaceuticals, Tarrytown, NY (D.M.W., S.S., T.N., S.A., H.G., R.B., B.J.M., Y. Soo, D.R., J.I., C. Perry, C. Pan, R.H., A.M., J.D.D., K.C.T., A.T.H., J.D.H., A.B., C.A.K., Y.K., A.C., W.K., B.K., T.D., N.S., L.L., N.B., G.H., G.D.Y.); Arizona Liver Health, Tucson (A.K.), and Arizona Liver Health, Chandler (Y. Sachdeva); and AGA Clinical Trials, Hialeah, FL (X.G.).
Leah LipsichFrom Regeneron Pharmaceuticals, Tarrytown, NY (D.M.W., S.S., T.N., S.A., H.G., R.B., B.J.M., Y. Soo, D.R., J.I., C. Perry, C. Pan, R.H., A.M., J.D.D., K.C.T., A.T.H., J.D.H., A.B., C.A.K., Y.K., A.C., W.K., B.K., T.D., N.S., L.L., N.B., G.H., G.D.Y.); Arizona Liver Health, Tucson (A.K.), and Arizona Liver Health, Chandler (Y. Sachdeva); and AGA Clinical Trials, Hialeah, FL (X.G.).
Ned BraunsteinFrom Regeneron Pharmaceuticals, Tarrytown, NY (D.M.W., S.S., T.N., S.A., H.G., R.B., B.J.M., Y. Soo, D.R., J.I., C. Perry, C. Pan, R.H., A.M., J.D.D., K.C.T., A.T.H., J.D.H., A.B., C.A.K., Y.K., A.C., W.K., B.K., T.D., N.S., L.L., N.B., G.H., G.D.Y.); Arizona Liver Health, Tucson (A.K.), and Arizona Liver Health, Chandler (Y. Sachdeva); and AGA Clinical Trials, Hialeah, FL (X.G.).
Gary HermanFrom Regeneron Pharmaceuticals, Tarrytown, NY (D.M.W., S.S., T.N., S.A., H.G., R.B., B.J.M., Y. Soo, D.R., J.I., C. Perry, C. Pan, R.H., A.M., J.D.D., K.C.T., A.T.H., J.D.H., A.B., C.A.K., Y.K., A.C., W.K., B.K., T.D., N.S., L.L., N.B., G.H., G.D.Y.); Arizona Liver Health, Tucson (A.K.), and Arizona Liver Health, Chandler (Y. Sachdeva); and AGA Clinical Trials, Hialeah, FL (X.G.).
George D YancopoulosFrom Regeneron Pharmaceuticals, Tarrytown, NY (D.M.W., S.S., T.N., S.A., H.G., R.B., B.J.M., Y. Soo, D.R., J.I., C. Perry, C. Pan, R.H., A.M., J.D.D., K.C.T., A.T.H., J.D.H., A.B., C.A.K., Y.K., A.C., W.K., B.K., T.D., N.S., L.L., N.B., G.H., G.D.Y.); Arizona Liver Health, Tucson (A.K.), and Arizona Liver Health, Chandler (Y. Sachdeva); and AGA Clinical Trials, Hialeah, FL (X.G.).
Trial Investigators
Funding
U.S. Department of Health and Human Services HHSO100201700020C
Abstract
backgroundRecent data suggest that complications and death from coronavirus disease 2019 (Covid-19) may be related to high viral loads.
methodsIn this ongoing, double-blind, phase 1-3 trial involving nonhospitalized patients with Covid-19, we investigated two fully human, neutralizing monoclonal antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein, used in a combined cocktail (REGN-COV2) to reduce the risk of the emergence of treatment-resistant mutant virus. Patients were randomly assigned (1:1:1) to receive placebo, 2.4 g of REGN-COV2, or 8.0 g of REGN-COV2 and were prospectively characterized at baseline for endogenous immune response against SARS-CoV-2 (serum antibody-positive or serum antibody-negative). Key end points included the time-weighted average change in viral load from baseline (day 1) through day 7 and the percentage of patients with at least one Covid-19-related medically attended visit through day 29. Safety was assessed in all patients.
resultsData from 275 patients are reported. The least-squares mean difference (combined REGN-COV2 dose groups vs. placebo group) in the time-weighted average change in viral load from day 1 through day 7 was -0.56 log
conclusionsIn this interim analysis, the REGN-COV2 antibody cocktail reduced viral load, with a greater effect in patients whose immune response had not yet been initiated or who had a high viral load at baseline. Safety outcomes were similar in the combined REGN-COV2 dose groups and the placebo group. (Funded by Regeneron Pharmaceuticals and the Biomedical and Advanced Research and Development Authority of the Department of Health and Human Services; ClinicalTrials.gov number, NCT04425629.).
Indexed as
COVID-19 Drug TreatmentAdultAntibodies, Monoclonal, HumanizedAntibodies, NeutralizingCOVID-19Double-Blind MethodDrug CombinationsFemaleHumansImmunologic FactorsLeast-Squares AnalysisMaleMiddle AgedOutpatientsReverse Transcriptase Polymerase Chain ReactionSARS-CoV-2Antibodies, Monoclonal, HumanizedAntibodies, Neutralizingcasirivimab and imdevimab drug combinationDrug CombinationsImmunologic Factors
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
NCT04425629ClinicalTrials.gov
NCT05502081ClinicalTrials.gov
NCT05648110ClinicalTrials.gov
NCT06917001ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.