ArticleEpilepsia2021
Factors correlated with intracranial interictal epileptiform discharges in refractory epilepsy.
Article in Epilepsia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 21 citations in OpenAlex.
- 40-Hz auditory stimulation for intracranial interictal activity: A pilot study.Acta neurologica Scandinavica · 2021Trial
- Synchrony is a robust iEEG biomarker for antiseizure medication load in epileptic patients.bioRxiv : the preprint server for biology · 2026Article
- Seizure onset zone (SoZ) identification from interictal intracranial electroencephalogram.Scientific reports · 2025Article
- Article
- Dissociating physiological ripples and epileptiform discharges with vision transformers.bioRxiv : the preprint server for biology · 2025Article
- The influence of temperature and genomic variation on intracranial EEG measures in people with epilepsy.Brain communications · 2024Article
- Interictal epileptiform discharges contribute to word-finding difficulty in epilepsy through multiple cognitive mechanisms.Epilepsia · 2023Article
- Evoked responses to note onsets and phrase boundaries in Mozart's K448.Scientific reports · 2022Article
- Musical components important for the Mozart K448 effect in epilepsy.Scientific reports · 2021Article
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Authors and funding
13 authors at 6 institutions in 1 country.
Funding
Abstract
objectiveThis study was undertaken to evaluate the influence that subject-specific factors have on intracranial interictal epileptiform discharge (IED) rates in persons with refractory epilepsy.
methodsOne hundred fifty subjects with intracranial electrodes performed multiple sessions of a free recall memory task; this standardized task controlled for subject attention levels. We utilized a dominance analysis to rank the importance of subject-specific factors based on their relative influence on IED rates. Linear mixed-effects models were employed to comprehensively examine factors with highly ranked importance.
resultsAntiseizure medication (ASM) status, time of testing, and seizure onset zone (SOZ) location were the highest-ranking factors in terms of their impact on IED rates. The average IED rate of electrodes in SOZs was 34% higher than the average IED rate of electrodes outside of SOZs (non-SOZ; p < .001). However, non-SOZ electrodes had similar IED rates regardless of the subject's SOZ location (p = .99). Subjects on older generation (p < .001) and combined generation (p < .001) ASM regimens had significantly lower IED rates relative to the group taking no ASMs; newer generation ASM regimens demonstrated a nonsignificant association with IED rates (p = .13). Of the ASMs included in this study, the following ASMs were associated with significant reductions in IED rates: levetiracetam (p < .001), carbamazepine (p < .001), lacosamide (p = .03), zonisamide (p = .01), lamotrigine (p = .03), phenytoin (p = .03), and topiramate (p = .01). We observed a nonsignificant association between time of testing and IED rates (morning-afternoon p = .15, morning-evening p = .85, afternoon-evening p = .26). SIGNIFICANCE: The current study ranks the relative influence that subject-specific factors have on IED rates and highlights the importance of considering certain factors, such as SOZ location and ASM status, when analyzing IEDs for clinical or research purposes.
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