ArticlePloS one2020
Viruses in unexplained encephalitis cases in American black bears (Ursus americanus).
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Rapid detection and genomic characterisation of feline chaphamaparvovirus in southwestern China.Journal of feline medicine and surgery · 2026Article
- First detection of two cycloviruses in cormorant fecal samples in China by high-throughput sequencing technology.Frontiers in veterinary science · 2025Article
- European Hedgehogs as Hosts of Chaphamaparvovirus, Italy.Animals : an open access journal from MDPI · 2024Article
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- 2024 taxonomy update for the family Circoviridae.Archives of virology · 2024Review
- Epidemiological and evolutionary analysis of canine circovirus from 1996 to 2023.BMC veterinary research · 2024Article
- Phylogenetic Analysis and Codon Usage Bias Reveal the Base of Feline and Canine Chaphamaparvovirus for Cross-Species Transmission.Animals : an open access journal from MDPI · 2023Article
- Novel Virus Identification through Metagenomics: A Systematic Review.Life (Basel, Switzerland) · 2022Review
- Epidemiology, genetic diversity, and association of canine circovirus infection in dogs with respiratory disease.Scientific reports · 2022Article
- Detection of FeChPV in a cat shelter outbreak of upper respiratory tract disease in China.Frontiers in microbiology · 2022Article
- Molecular characterization ofJournal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2022Article
- Detection and Complete Genome Analysis of Circoviruses and Cycloviruses in the Small Indian Mongoose (Viruses · 2021Article
- Circovirus in Blood of a Febrile Horse with Hepatitis.Viruses · 2021Article
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Viral infections were investigated in American black bears (Ursus americanus) from Nevada and northern California with and without idiopathic encephalitis. Metagenomics analyses of tissue pools revealed novel viruses in the genera Circoviridae, Parvoviridae, Anelloviridae, Polyomaviridae, and Papillomaviridae. The circovirus and parvovirus were of particular interest due to their potential importance as pathogens. We characterized the genomes of these viruses and subsequently screened bears by PCR to determine their prevalence. The circovirus (Ursus americanus circovirus, UaCV) was detected at a high prevalence (10/16, 67%), and the chaphamaparvovirus (Ursus americanus parvovirus, UaPV) was found in a single bear. We showed that UaCV is present in liver, spleen/lymph node, and brain tissue of selected cases by in situ hybridization (ISH) and PCR. Infections were detected in cases of idiopathic encephalitis and in cases without inflammatory brain lesions. Infection status was not clearly correlated with disease, and the significance of these infections remains unclear. Given the known pathogenicity of a closely related mammalian circovirus, and the complex manifestations of circovirus-associated diseases, we suggest that UaCV warrants further study as a possible cause or contributor to disease in American black bears.
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