Evidence map›Paper›PMID 33332247›Full record

ArticleAmerican journal of respiratory and critical care medicine2021

Lipid-laden Macrophages Are Not Unique to Patients with E-Cigarette or Vaping Product Use-associated Lung Injury.

Arunava Ghosh, Saira Ahmad, Raymond D Coakley, M Flori Sassano, Neil E Alexis, Robert Tarran

Abstract readLetter
In one paragraph

Article in American journal of respiratory and critical care medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Vaping-related lung disease: a narrative review.Journal of thoracic disease · 2026
    Review
  3. Review
  4. CYP1B1 Mediates Cigarette Smoke-Induced Lipid Accumulation in Alveolar Type 2 Cells.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  5. E-Cigarette or Vaping Product Use-Associated Lung Injury: A Comprehensive Review.International journal of environmental research and public health · 2025
    Review
  6. Article
  7. E-cigs put the squeeze on macrophages.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  8. Article
  9. Article
  10. Predicting the pulmonary effects of long-term e-cigarette use: are the clouds clearing?European respiratory review : an official journal of the European Respiratory Society · 2022
    Review
  11. Chronic E-Cigarette Exposure Alters Human Alveolar Macrophage Morphology and Gene Expression.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2022
    Article
  12. Combustible and Electronic Cigarette Exposures Increase ACE2 Activity and SARS-CoV-2 Spike Binding.American journal of respiratory and critical care medicine · 2022
    Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Arunava GhoshUniversity of North Carolina at Chapel Hill Chapel Hill, North Carolina.
Saira AhmadUniversity of North Carolina at Chapel Hill Chapel Hill, North Carolina.
Raymond D CoakleyUniversity of North Carolina at Chapel Hill Chapel Hill, North Carolina.
M Flori SassanoUniversity of North Carolina at Chapel Hill Chapel Hill, North Carolina.
Neil E AlexisUniversity of North Carolina at Chapel Hill Chapel Hill, North Carolina.
Robert TarranUniversity of North Carolina at Chapel Hill Chapel Hill, North Carolina.ORCID 0000-0002-8598-2642

Funding

The Impact of Tobacco Exposure on the Lungs Innate Defense SystemP50HL120100 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI RANDELL, SCOTT H · 2013 to 2017
$21.0M
The effect of Inhaled Nicotine on Pulmonary SurfacesR01HL135642 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KESIMER, MEHMET, TARRAN, ROBERT · 2017 to 2021
$2.9M
Do E-Cigarette Users Airways Have an Altered Lipid Content?R21HL153698 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI TARRAN, ROBERT · 2020 to 2021
$428k
NHLBI NIH HHS P50 HL120100NHLBI NIH HHS R01 HL135642NHLBI NIH HHS R21 HL153698
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AdultAgedAged, 80 and overElectronic Nicotine Delivery SystemsFemaleHumansLipidsLung InjuryMacrophagesMaleMiddle AgedVapingLipids

Identifiers

PMID33332247
PMCPMC8048758

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.