ArticleEnvironmental health perspectives2020
Urinary Arsenic and Cadmium Associations with Findings from Cranial MRI in American Indians: Data from the Strong Heart Study.
Article in Environmental health perspectives, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- Effect of an Arsenic Mitigation Program on Arsenic Exposure in American Indian Communities: A Cluster Randomized Controlled Trial of the Community-Led Strong Heart Water Study Program.Environmental health perspectives · 2024Trial
- Behavioral determinants of arsenic-safe water use among Great Plains Indian Nation private well users: results from the Community-Led Strong Heart Water Study Arsenic Mitigation Program.Environmental health : a global access science source · 2023Trial
- Evaluation of a water arsenic filter in a participatory intervention to reduce arsenic exposure in American Indian communities: The Strong Heart Water Study.The Science of the total environment · 2023Trial
- Risk factors and population attributable fraction for dementia in American Indians: The Strong Heart Study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Epidemiology of Head Injury and Associations with Clinical and Neuropsychological Test Scores in Older American Indians: Data from the Strong Heart Study.Journal of racial and ethnic health disparities · 2026Article
- Environmental Risk in American Indian Children, Including Cardiovascular and Hematologic Consequences of Cadmium Exposure: Possible Means of Mitigation.International journal of environmental research and public health · 2025Review
- Urinary selenium, cranial MRI, and cognitive function in American Indians: The Strong Heart Study.Environmental research · 2025Article
- The impact of psychosocial adversity on brain and behaviour: an overview of existing knowledge and directions for future research.Molecular psychiatry · 2024Review
- Sequencing-based fine-mapping and in silico functional characterization of the 10q24.32 arsenic metabolism efficiency locus across multiple arsenic-exposed populations.PLoS genetics · 2023Article
- Psychological and social support associations with mortality and cardiovascular disease in middle-aged American Indians: the Strong Heart Study.Social psychiatry and psychiatric epidemiology · 2022Article
- Excretion of Heavy Metals and Glyphosate in Urine and Hair Before and After Long-Term Fasting in Humans.Frontiers in nutrition · 2021Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundArsenic and cadmium are known cardiovascular toxicants that pose disproportionate risk to rural communities where environmental exposures are high. American Indians have high vascular risk, which may be attributable in part to these exposures.
objectiveWe examined urine metal concentrations in association with magnetic resonance imaging findings of vascular brain injury or cerebral atrophy in adult American Indians.
methodsWe measured arsenic and cadmium in American Indian participants from the Strong Heart Study (1989-1991) and evaluated these associations with later (2010-2013) measures of infarct, hemorrhage, white matter hyperintensity (WMH) grade, brain and hippocampal volume, and sulcal and ventricle atrophy using nested multivariate regression analyses.
resultsAmong participants with available data ( DISCUSSION: This population-based cohort of American Indian elders had measured values of urine arsenic and cadmium several times higher than previous population- and clinic-based studies in the United States and Mexico, and comparable values with European industrial workers. Our findings of associations for arsenic and cadmium exposures with vascular brain injury are consistent with established literature. Environmental toxicant accumulation is modifiable; public health policy may benefit from focusing on reductions in environmental metals. https://doi.org/10.1289/EHP6930.
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