ArticleCirculation. Genomic and precision medicine2021
Sexual Differences in Genetic Predisposition of Coronary Artery Disease.
Article in Circulation. Genomic and precision medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27 citing papers in PubMed, 48 citations in OpenAlex.
- Sex-stratified polygenic risk scores for coronary artery disease incidence: Insights from a 20-year cohort study.BMC cardiovascular disorders · 2026Article
- Unraveling the genetic blueprint of coronary artery disease: The role of polygenic risk scores in risk prediction.American heart journal plus : cardiology research and practice · 2026Article
- Sex differences in the associations of multidomain risk factor profiles with incident major adverse cardiovascular events.Frontiers in cardiovascular medicine · 2026Article
- Large-Scale Proteomics-Based Risk Score for the Prediction of Incident Cardio-Kidney-Metabolic Disease Risk.Circulation. Genomic and precision medicine · 2025Article
- Genetic analyses across cardiovascular traits: leveraging genetic correlations to empower locus discovery and prediction in common cardiovascular diseases.NPJ genomic medicine · 2025Article
- A semi-empirical Bayes approach for calibrating weak instrumental bias in sex-specific Mendelian randomization studies.American journal of human genetics · 2025Article
- Sex differences in proteomics of cardiovascular disease -International journal of cardiology. Heart & vasculature · 2025Article
- Article
- Sex differences in predicting dyslipidemia using polygenic risk score with fatty liver index and fibrotic nonalcoholic steatohepatitis index.Scientific reports · 2025Article
- Artificial intelligence-enhanced electrocardiography improves the detection of coronary artery disease.Computational and structural biotechnology journal · 2025Article
- Proteomics-Based Soluble Urokinase Plasminogen Activator Receptor Levels Are Associated With Incident Heart Failure Risk.JACC. Advances · 2025Article
- Identification of Disease-Relevant, Sex-Based Proteomic Differences in iPSC-Derived Vascular Smooth Muscle Cells.International journal of molecular sciences · 2024Article
- Genome-Wide European Ancestry Study Identifies Coronary Artery Disease-Associated Loci Through Gene-Sex Hormone Interaction.Journal of the American Heart Association · 2024Article
- A unified framework for estimating country-specific cumulative incidence for 18 diseases stratified by polygenic risk.Nature communications · 2024Article
- Review
- Predictive value of systemic inflammatory response index (SIRI) for complex coronary artery disease occurrence in patients presenting with angina equivalent symptoms.Cardiology journal · 2024Article
- Additive interaction of family medical history of cardiovascular diseases with hypertension and diabetes on the diagnosis of cardiovascular diseases among older adults in India.Frontiers in cardiovascular medicine · 2024Article
- Sex-Specific Survival Bias and Interaction Modeling in Coronary Artery Disease Risk Prediction.Circulation. Genomic and precision medicine · 2023Article
- Large-scale genome-wide association study of coronary artery disease in genetically diverse populations.Nature medicine · 2022Article
- Association Between High-Density Lipoprotein Cholesterol Levels and Adverse Cardiovascular Outcomes in High-risk Populations.JAMA cardiology · 2022Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe genomic structure that contributes to the risk of coronary artery disease (CAD) can be evaluated as a risk score of multiple variants. However, sex differences have not been fully examined in applications of genetic risk score (GRS) of CAD.
methodsUsing data from the UK Biobank, we constructed a CAD-GRS based on all known loci, 3 mediating trait-based (blood pressure, lipids, and body mass index) subscores, and a genome-wide polygenic risk score based on 1.1 million variants. The differences in genetic associations with prevalent and incident CAD between men and women were investigated among 317 509 unrelated individuals of the European ancestry. We also assessed interactions with sex for 161 individual loci included in the comprehensive GRS.
resultsFor both prevalent and incident CAD, the associations of comprehensive and genome-wide GRSs were stronger among men than women. Using a score of 161 loci, we observed a 2.4× higher risk for incident CAD comparing men with high genetic risk to men with low genetic risk but an 80% greater risk comparing women with high genetic risk to women with low genetic risk (interaction
conclusionsSexual differences in genetic predisposition should be considered in future studies of CAD, and GRSs should not be assumed to perform equally well in men and women.
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