ReviewAdvances in experimental medicine and biology2021
Cannabis and Depression.
Review in Advances in experimental medicine and biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 80 citations in OpenAlex.
- The antidepressant and anxiolytic effects of cannabinoids in chronic unpredictable stress: a preclinical systematic review and meta-analysis.Translational psychiatry · 2022Pooled it
- Cannabis use and glutamate across the psychosis spectrum: in vivo evidence from 7T proton magnetic resonance spectroscopy.Molecular psychiatry · 2026Article
- Canadian real-world evidence: observational 24-week outcomes for health care practitioner authorized cannabis.Canadian journal of pain = Revue canadienne de la douleur · 2026Article
- Ethnic variations in sedentary behavior and marijuana use among U.S. adults: A cross-sectional analysis.Medicine · 2025Article
- Cannabis Use and Glutamate across the Psychosis Spectrum: In Vivo Evidence from 7T Proton Magnetic Resonance Spectroscopy.Research square · 2025Article
- Cannabis use disorder risks among Medicaid enrollees with comorbid psychiatric illnesses: 2012-2021.Drug and alcohol dependence · 2025Article
- Cannabinoid profiling across toxicology samples in adolescents and young adults by route of administration and in relation to depression symptoms.Journal of analytical toxicology · 2025Article
- Smoked or Bewitched? The Relationship Between Cannabis Use and Mental Illness Among the Shona Persons in Zimbabwe.Culture, medicine and psychiatry · 2025Article
- The Association Between Marijuana Use and Myocardial Infarction, Asthma, and Depression in Racial and Sexual Minorities: BRFSS 2016-2022.AJPM focus · 2025Article
- Rapid Specific PCR Detection Based onInternational journal of molecular sciences · 2025Article
- Hazardous Drinking and Cannabis Use in Military Veterans: Comparative Associations with Risk for Suicidal and Non-Suicidal Self-Injury.International journal of mental health and addiction · 2025Article
- Development of an anxiety disorder following an emergency department visit due to cannabis use: a population-based cohort study.EClinicalMedicine · 2024Article
- Cannabinoid type-1 receptor signaling in dopaminergic Engrailed-1 expressing neurons modulates motivation and depressive-like behavior.Frontiers in molecular neuroscience · 2024Article
- Cannabinoids and the Endocannabinoid System in Early SARS-CoV-2 Infection and Long COVID-19-A Scoping Review.Journal of clinical medicine · 2023Article
- Chronic disease clusters are associated with prolonged, bothersome, and multisite musculoskeletal pain: a population-based study on Northern Finns.Annals of medicine · 2023Article
- Neuroimaging in Adolescents: Post-Traumatic Stress Disorder and Risk for Substance Use Disorders.Genes · 2023Review
- Syncope and Cannabis: hypervagotonia from chronic abuse? A case report and literature review.BMC cardiovascular disorders · 2023Review
- Chronic exposure to a synthetic cannabinoid alters cerebral brain metabolism and causes long-lasting behavioral deficits in adult mice.Journal of neural transmission (Vienna, Austria : 1996) · 2023Article
- Prospective associations between cannabis use and depressive symptoms across adolescence and early adulthood.Psychiatry research · 2023Article
- Avatar Intervention for Cannabis Use Disorder in Individuals with Severe Mental Disorders: A Pilot Study.Journal of personalized medicine · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is a growing body of evidence pointing to the co-occurrence of cannabis use and depression. There is also some evidence that the use of cannabis may lead to the onset of depression; however, strong evidence points to the inverse association; i.e. that depression may lead to the onset or increase in cannabis use frequency. Observational and epidemiological studies have not indicated a positive long-term effect of cannabis use on the course and outcome of depression. The association between cannabis use and depression may be stronger among men during adolescence and emerging adulthood and stronger in women during midlife. There is an indication for potential genetic correlation contributing to the comorbidity of cannabis dependence and major depression, namely that serotonin (5-HT) may mediate such association and there is also evidence for specific risk alleles for cannabis addiction. There is preclinical evidence that alteration in the endocannabinoid system could potentially benefit patients suffering from depression. However, the issue of using cannabis as an anti-depressant is at an early stage of examination and there is little evidence to support it. Finally, there has been little support to the notion that selective serotonin reuptake inhibitors (SSRIs) may be effective in decreasing depressive symptoms or rates of substance use in adolescents treated for depression and a co-occurring substance use disorder. In conclusion, despite methodological limitations, research in the past decades has broadened our knowledge on the association between cannabis use and depression from epidemiological, neurological, genetic, and pharmacological perspectives.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.